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Vectormune HVT NDV & SB-1

This treatment applies to the following species:
Company: Ceva Biomune


Live Marek’s Disease Vector

Directions For Use


VECTORMUNE® HVT NDV & SB-1 contains a genetically engineered Marek’s disease vaccine of serotype 3 (turkey herpesvirus or HVT) expressing a Newcastle disease key protective antigen and a serotype 2 (SB-1) Marek’s disease vaccine. The combination vaccine is recommended for use in chickens as an aid in the prevention of Newcastle disease and very virulent Marek’s disease. The bivalent Marek’s disease vaccine containing serotypes 2 and 3 is presented in a frozen cell associated form. The cells and virus particles are very fragile and require careful handling to prevent damage or loss of titer in order to achieve optimum efficacy. The vaccine is stored and shipped in frozen form in liquid nitrogen.

Storage Conditions

- Vaccine ampules: Store in liquid nitrogen

- Diluent: Store at room temperature between 68-77°F (20-25°C) or 2-7°C

Vectormune HVT NDV & SB-1 Indications

The vaccine is recommended for use in healthy one-day-old chicks or in 18 to 19 day-old embryonating chicken eggs as an aid in the prevention of Newcastle disease and Marek’s disease caused by very virulent Marek’s disease. Good management practices are recommended to reduce exposure to Newcastle disease virus and Marek’s disease virus for at least two weeks following vaccination.

Preparation And Administration Of Vaccine

Carefully read the directions before use. The instructions must be completely followed. Match the vaccine dose size to the proper diluent size and route of administration as follows:

1. For subcutaneous injection of day-old chicks - Mix 200 ml of diluent for each 1000 doses of vaccine.

2. For in ovo vaccination of 18 to 19 day-old chicken embryos - Mix 100 ml of diluent for each 1000 doses of vaccine to administer 0.1 ml per chicken embryo or mix 50 ml for each 1,000 doses of vaccine to administer 0.05 ml per chicken embryo.


1. Be familiar with all safety and precautionary measures for handling liquid nitrogen to prevent personal injury.

2. Wear gloves, a plastic face shield and protective goggles before removing vaccine ampules from the liquid nitrogen.

3. Check the container to confirm a sufficient amount of liquid nitrogen is present to keep the vaccine frozen. If thawed, do not use the vaccine. The containers must be checked regularly for liquid nitrogen level and must be refilled as needed.

4. After matching the dose size of the vaccine with the diluent size, quickly remove the exact number of ampules needed.

5. A maximum of 4 ampules should be thawed at one time. After inspecting the diluent and completing all preparations, the vaccine should be quickly removed from the Dewar and placed into a clean 80°F (26.5°C) thaw bath. This step can be repeated until the appropriate dosage has been reached. Gentle agitation during the thawing process promotes rapid, even thawing and evenly distributes the vaccine in the ampule.

6. Immediately after thawing, mix the vaccine with the diluent at room temperature (68-77°F or 20-25°C). Gently draw the vaccine from the ampule with an 18-gauge, 1.5 inch needle and slowly mix with the diluent. Rinse the ampule one time with the diluted vaccine.

7. Immediately use the vaccine and mix occasionally to ensure uniform suspension of cells. The recommended dose is 0.2 ml per chick for subcutaneous vaccination. The recommended dose is 0.1 ml per embryo for in ovo vaccination.


1. For subcutaneous injection, sterilize the automatic syringe, needles and other accessory equipment by autoclaving or boiling prior to vaccination.

2. Use a short (3/8 inch or 1/2 inch) 20-gauge needle for vaccination. Subcutaneously inject 0.2 ml into the back of the neck of each chick.


1. The vaccine is administered in ovo to 18 to 19 day-old embryonating eggs. Read the egg injection system operator’s manual before initiating vaccination. Failure to follow instructions may result in personal injury, excessive embryonic mortality and low hatchability. The recommended dose is 0.1 ml per embryo for in ovo vaccination.

2. Sanitize the egg injection system before and after use following the procedures described in the operator’s manual.


This vaccine has been thoroughly tested for safety, purity and potency and is in compliance with all applicable USDA and Biomune Co. standards.

Vectormune HVT NDV & SB-1 Caution

1. Read the above directions carefully.

2. Do not vaccinate within 21 days before slaughter.

3. The vaccine contains gentamicin and amphotericin B as preservatives.

4. Burn containers and all unused contents.

5. Do not remove vaccine from liquid nitrogen until ready for use.

6. Do not refreeze the vaccine.

7. Do not use vaccine that has thawed in the liquid nitrogen container.

8. Do not overdose or over dilute the vaccine.

9. The effect of combining this vaccine with other products is not known and could impact vaccine efficacy.

Patent Numbers US 6632664, US 5310678 and US 6866852

Biomune Co., Lenexa, Kansas 66215, U.S.A.

Phone: (913) 894-0230

U.S. Vet Lic. No. 368


Presentation: 2,000 dose and 4,000 dose ampoules delivered in liquid nitrogen dewars.

CPN: 11290582

Telephone:   913-894-0230
Fax:   913-894-0236
THIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.


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