Vectormune HVT AIV

Company: Ceva Animal Health

AVIAN INFLUENZA-MAREK’S DISEASE, H5 Subtype, Serotype 3, Live Marek’s Disease Vector

Directions For Use

Description

VECTORMUNE^® HVT AIV contains a genetically engineered Marek’s disease virus of serotype 3 (turkey herpesvirus or HVT) expressing an avian influenza H5 type key protective antigen. This Marek’s disease vaccine containing serotype 3 is presented in a frozen cell associated form. The cells and virus particles are very fragile and require careful handling to prevent damage or loss of titer in order to achieve optimum efficacy. The vaccine is stored and shipped in frozen form in liquid nitrogen.

STORAGE CONDITIONS

● Vaccine ampules: Store in liquid nitrogen

● Diluent: Store at room temperature between 68-77°F (20-25°C)

Vectormune HVT AIV Indications

This product has been shown to be effective for the vaccination of healthy chickens 1 day of age or older against avian influenza caused by the H5 subtype and Marek’s disease. The duration of immunity is unknown. Good management practices are recommended to reduce exposure to Marek’s disease virus for at least two weeks following vaccination.

Preparation And Administration Of Vaccine

Carefully read the directions before use. The instructions must be completely followed. Match the vaccine dose size to the proper diluent size as follows: Mix 200 mL of diluent for each 1,000 doses of vaccine. One-day-old chicks are subcutaneously vaccinated with 0.2 mL of vaccine in the back of the neck.

VACCINE PREPARATION

1. Be familiar with all safety and precautionary measures for handling liquid nitrogen to prevent personal injury.

2. Wear gloves, a plastic face shield and protective goggles before removing vaccine ampules from the liquid nitrogen.

3. Check the container to confirm a sufficient amount of liquid nitrogen is present to keep the vaccine frozen. If thawed, do not use the vaccine. The containers (Dewars) must be checked regularly for liquid nitrogen level and must be refilled as needed.

4. After matching the dose size of the vaccine with the diluent size, quickly remove the exact number of ampules needed.

5. A maximum of 3 ampules should be thawed at one time. After inspecting the diluent and completing all preparations, the vaccine should be quickly removed from the Dewar and placed into a clean 80°F (26.5°C) thaw bath. This step can be repeated until the appropriate dosage has been reached. Gentle agitation during the thawing process promotes rapid, uniform thawing and evenly distributes the vaccine in the ampule.

6. Immediately after thawing, mix the vaccine with the diluent at room temperature (68-77°F or 20-25°C). Gently draw the vaccine from the ampule with an 18-gauge, 1.5 inch needle and slowly mix with the diluent. Rinse the ampule one time with the diluted vaccine.

7. Immediately use the vaccine and mix occasionally to ensure uniform suspension of cells.

SUBCUTANEOUS VACCINATION

1. For subcutaneous injection, sterilize the automatic syringe, needles and other accessory equipment by autoclaving or boiling prior to vaccination.

2. Use a short (3/8 inch or 1/2 inch) 20-gauge needle for vaccination. Subcutaneously inject 0.2 mL into the back of the neck of each chick.

Notice

This vaccine has been thoroughly tested for safety, purity and potency and is in compliance with all applicable USDA, CFIA and Ceva standards.

Vectormune HVT AIV Caution

1. Read the above directions carefully.

2. Do not vaccinate within 21 days before slaughter.

3. The vaccine contains gentamicin and amphotericin B as preservatives.

4. Inactivate unused contents before disposal.

5. Do not remove vaccine from liquid nitrogen until ready for use.

6. Do not refreeze vaccine.

7. Use entire contents when first opened.

8. Do not use vaccine that has thawed in the liquid nitrogen container.

9. Do not overdose or over dilute the vaccine.

10. Do not mix with other products, except as specified on the label.

11. The effect of combining this vaccine with other products is not known and could impact vaccine efficacy.

12. In case of human exposure, contact a physician.

13. For use in animals only.

14. This product may only be distributed and used in the United States of America or Canada as part of an official USDA or CFIA animal disease program

Ceva Animal Health, LLC, Lenexa, Kansas 66215, U.S.A.

Phone: (913) 894-0230

VLN 368/PCN 1062.R0

PX395XXUS-101

Presentation: 1,000 doses, 2,000 doses, and 4,000 doses.

CPN: 1129076.1