Tylan Soluble (Canada)

tylosin tartrate

DIN 00103616

FOR VETERINARY USE ONLY

Antibiotic

Active Ingredient

Each jar contains tylosin (as tylosin tartrate) 100 g.

Tylan Soluble Indications

FOR USE IN PIGS

1. As an aid in the treatment of swine dysentery (bloody scours).

2. As an aid in the treatment of porcine proliferative enteropathy (PPE) or ileitis associated with Lawsonia intracellularis.

FOR USE IN CHICKENS

1. As an aid in the treatment of chronic respiratory disease (CRD) in broilers and replacement flocks or for the prevention of CRD at the time of vaccination or other stress.

2. As an aid in the treatment of necrotic enteritis caused by Clostridium perfringens in broiler chickens.

For Use In Turkeys

As an aid in the treatment or for the prevention of infectious sinusitis.

For Use In Honey Bees

As an aid in the treatment of American Foulbrood (Paenibacillus larvae) in honey bees (Apis mellifera).

Mixing

PIGS, CHICKENS, TURKEYS:

To assure thorough dissolving, place the Tylan Soluble (contents of this package) in a one-gallon or 5 litre mixing container and add the water to the Tylan Soluble powder. Always add the water to the powder. Do not pour the powder into the water.

HONEY BEES:

Mix 200 mg tylosin in 20 g confectioners/powdered sugar. Use immediately.

Directions For Use

To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently.

PIGS

1. As an aid in the treatment of swine dysentery (bloody scours):

● Treat by way of the drinking water for 3 to 10 days at 1 g per 4 litres (250 mg/litre).

● To make a solution of 1 gram per 4 litres (250 mg/litre) mix the contents of this package with 400 litres (approximately 100 U.S. gallons or 80 Imperial gallons).

2. As an aid in the treatment of porcine proliferative enteropathy (PPE) or ileitis associated with Lawsonia intracellularis:

● Treat by way of drinking water for 14 days at 1 g per 12 litres (83 mg/litre), or by way of drinking water for 7 days at 1 g per 12 litres (83 mg/litre) followed by Elanco Tylan in the feed at 110 mg/kg for 7 days.

● To make a solution of 1 g per 12 litres (83 mg/litre) mix the contents of this package with 1200 litres (approximately 320 U.S. gallons or 265 Imperial gallons).

CHICKENS

1. As an aid in the treatment of chronic respiratory disease (CRD) in broilers and replacement flocks or for the prevention of CRD at the time of vaccination or other stress:

● Treat by way of the drinking water for 3 days at 2 g per 4 litres (500 mg/litre); however, treatment may be administered for 1 to 5 days depending on the severity of infection.

● For the prevention of Chronic Respiratory Disease (CRD) at the time of vaccination or other stress:
CHICKENS should be treated for the first 3 days of life. Repeat treatment for 1 day at 3 to 4 weeks of age, to coincide with vaccination or other stress.

● To make a solution of 2 g per 4 litres (500 mg/litre) mix the contents of this package with 200 litres (approximately 50 U.S. gallons or 40 Imperial gallons).

2. As an aid in the treatment of necrotic enteritis caused by Clostridium perfringens in broiler chickens:

● Treat by way of the drinking water for 5 days at not less than 100 mg/litre (0.4 g per 4 litres) and not more than 150 mg/litre (0.6 g per 4 litres) depending on the severity of the necrotic enteritis outbreak.

● In order to provide not less than 100 mg/litre and not more than 150 mg/litre, make a solution of not less than 0.4 g per 4 litres (mix contents of package with 1000 litres or approximately 264 U.S. gallons or 220 Imperial gallons) and not more than 0.6 g per 4 litres (mix contents of package with 660 litres or approximately 175 U.S. gallons or 145 Imperial gallons).

Turkeys

As an aid in the treatment or for the prevention of infectious sinusitis:

● Treat by way of the drinking water for 3 days at 2 g per 4 litres (500 mg/litre); however, treatment may be administered for 2 to 5 days depending on the severity of infection.

● For the prevention of infectious sinusitis in turkeys:
TURKEYS should be treated for the first 5 days of life. Repeat treatment for 2 days at 4 weeks of age.

● To make a solution of 2 g per 4 litres (500 mg/litre) mix the contents of this package with 200 litres (approximately 50 U.S. gallons or 40 Imperial gallons).

Prepare a fresh Tylan solution every 3 days.

Honey Bees

As an aid in the treatment of American Foulbrood (Paenibacillus larvae) in honey bees (Apis mellifera):

● Colonies should receive three treatments administered as a dust in confectioners/powdered sugar. The 200 mg dose is applied (dusted) over the top bars of the brood chamber once weekly for 3 weeks.

In all species: If improvement is not observed within 5 days, the diagnosis should be reconfirmed.

Medicated water should be the only source of drinking water during the treatment period.

Administering the appropriate therapeutic dose is important to maximize performance and avoid the development of resistance to this medication.

Tylan Soluble Cautions

Treatment with Tylan Soluble does not eradicate American Foulbrood disease, as the Paenibacillus larvae spores may still be present. The clinical signs of American Foulbrood disease may therefore be masked and consequently, there may be a risk of spreading the disease by the movement of infected materials between apiaries.

Tylan Soluble should be used only in honey bee colonies showing active signs of American Foulbrood disease.

Warnings

TREATED PIGS administered 1 g of tylosin per 4 L (250 mg/litre) of drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with this drug.

TREATED CHICKENS administered 2 g of tylosin per 4 L (500 mg/litre) of drinking water must not be slaughtered for use in food for at least 24 hours after the latest treatment with this drug. Do not use in laying hens.

TREATED TURKEYS must not be slaughtered for use in food for at least 72 hours after the latest treatment with this drug.

HONEY BEES: To avoid violative residues in honey, Tylan Soluble should be fed early in the spring or fall and consumed by the bees before the main honey flow begins. Complete treatments at least 4 weeks prior to main honey flow. Honey collected in supers before the end of the 4 week withdrawal period should not be harvested for human consumption. Honey from brood nest areas of colonies treated with Tylan Soluble should not be harvested for human consumption.

When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes.

Keep out of reach of children.

NOTE: No withdrawal period is required when the drug is used as an aid in the treatment of porcine proliferative enteropathy (PPE), or ileitis, at 1 g of tylosin per 12 L (83 mg/litre) of drinking water, in pigs. No withdrawal period is required when the drug is used as an aid in the treatment of necrotic enteritis, at the dose range of 100 to 150 mg/litre, in broiler chickens.

Storage: Store at a temperature below 25°C.

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Elanco Canada Limited, 1919 Minnesota Court, Suite 401, Mississauga, Ontario L5N 0C9

CPN: 1231139.2