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Terramycin Ophthalmic Ointment

This page contains information on Terramycin Ophthalmic Ointment for veterinary use.
The information provided typically includes the following:
  • Terramycin Ophthalmic Ointment Indications
  • Warnings and cautions for Terramycin Ophthalmic Ointment
  • Direction and dosage information for Terramycin Ophthalmic Ointment

Terramycin Ophthalmic Ointment

This treatment applies to the following species:
Manufacturer: Zoetis

(Oxytetracycline Hydrochloride and Polymyxin B Sulfate Ophthalmic Ointment)


Ophthalmic Ointment


Terramycin (Oxytetracycline Hydrochloride and Polymyxin B Sulfate Ophthalmic Ointment) is an antibiotic, bright yellow in color, possessing potent antimicrobial activity. It is one of the most versatile of the broad-spectrum antibiotics, and is effective in the treatment of infections due to gram-positive and gram-negative bacteria, both aerobic and anaerobic, spirochetes, rickettsiae, and certain of the larger viruses.

Polymyxin B sulfate is one of a group of related antibiotics derived from Bacillus polymyxa. The polymyxins are rapidly bactericidal, this action being exclusively against gram-negative bacteria.

The broad-spectrum effectiveness of Terramycin against both gram-positive and gram-negative organisms is enhanced by the particular effectiveness of polymyxin B against infections associated with gram-negative organisms, especially those due to Pseudomonas aeruginosa, where polymyxin B is the antibiotic of choice. In addition, there is evidence to indicate that polymyxin B sulfate possesses some antifungal activity. The combined antibacterial effect of Terramycin plus polymyxin is at least additive and, in many instances, an actual synergistic action is obtained.

Terramycin is an ointment of oxytetracycline hydrochloride and polymyxin B sulfate in a special petrolatum base. Each gram of ointment contains oxytetracycline HCl equivalent to 5 mg of oxytetracycline and 10,000 units of polymyxin B as the sulfate.

Terramycin Ophthalmic Ointment Indications and Usage

Terramycin is indicated for the prophylaxis and local treatment of superficial ocular infections due to oxytetracycline and polymyxin-sensitive organisms, including infections due to streptococci, rickettsiae, E. coli, and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due to secondary bacterial complications of distemper in dogs, and bacterial inflammatory conditions which may occur secondary to other infectious diseases in the above species.

WARNING: Serious, life threatening, hypersensitivity (anaphylactic) reactions have been reported in some cats following application of antibiotic ophthalmic preparations. If your cat has swelling of the face, itching, appears weak, vomits, or has difficulty breathing within 4 hours of application you should discontinue treatment and contact your veterinarian immediately.

Note: The use of oxytetracycline and other antibiotics may result in an overgrowth of resistant organisms such as Monilia, staphylococci, and other species of bacteria. If new infections due to nonsensitive bacteria or fungi appear during therapy, appropriate measures should be taken.

Dosage and Administration

Terramycin (Oxytetracycline Hydrochloride and Polymyxin B Sulfate Ophthalmic Ointment) should be administered topically to the eye 2-4 times daily.

RECOMMENDED STORAGE: Store at controlled room temperature between 20° to 25°C (68° to 77°F), with excursions between 15° to 30°C (59° to 86°F).

How Supplied

1/8-oz (3.5-g) tube

For Animal Use Only

Restricted Drug (California)-Use Only As Directed

Not for Human Use

NADA #8-763, Approved by FDA

Distributed by: Zoetis Inc., Kalamazoo, MI 49007

Made in Switzerland

Revised: June 2017


CPN: 3690179.4

Telephone:   269-359-4414
Customer Service:   888-963-8471
Every effort has been made to ensure the accuracy of the Terramycin Ophthalmic Ointment information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2018 North American Compendiums. Updated: 2018-02-26