Phenylzone Paste

Phenylzone Paste Indications

For the relief of inflammatory conditions associated with the musculoskeletal system in horses.

Contraindications

Use with caution in patients who have a history of drug allergy.

Warning

Do not use in horses intended for human consumption.

Precautions

Stop medication at the first sign of gastrointestinal upset, jaundice, or blood dyscrasia. Authenticated cases of agranulocytosis associated with the drug have occurred in man; fatal reactions, although rare, have been reported in dogs after long-term therapy. To guard against this possibility, conduct routine blood counts at weekly intervals during the early phase of therapy and at intervals of 2 weeks thereafter. Any significant fall in the total white count, relative decrease in granulocytes, or black or tarry stools, should be regarded as a signal for immediate cessation of therapy and institution of appropriate countermeasures. In the treatment of inflammatory conditions associated with infections, specific anti-infective therapy is required.

ADMINISTRATION AND DOSAGE:

Orally - 1 to 2 g of phenylbutazone per 500 lb (227 kg) of body weight, but not to exceed 4 g daily. Use a relatively high dose for the first 48 hours, then reduce gradually to a maintenance dose. Maintain lowest dose capable of producing desired clinical response.

Guidelines to Successful Therapy:

1. Important - To avoid overdosing and to ensure the correct first dose, move ring on plunger to the appropriate dosage position before administration (see Figure 1). The edge of the ring closest to the syringe barrel should be aligned to the gram/dosage mark on the plunger.

2. When administering PHENYLZONE Paste the oral cavity should be empty. Set ring on plunger to deliver the appropriate dosage based on weight (see Figure 1). Deposit paste on the back of tongue by depressing plunger.

3. Use a relatively high dose for the first 48 hours (not to exceed 4 g daily), then reduce gradually to a maintenance dose. Maintain lowest dose capable of producing desired clinical response.

4. Response to PHENYLZONE Paste therapy is prompt, usually occurring within 24 hours. If no significant clinical response is evident after 5 days, reevaluate diagnosis and therapeutic approach.

5. Many chronic conditions will respond to PHENYLZONE Paste therapy, but discontinuance of treatment may result in recurrence of symptoms.

Storage

Store at 15°-25° C (59°-77° F).

How Supplied

Syringes containing 12 g of phenylbutazone, NDC 0061-5040-01 (12 g).

KEEP OUT OF REACH OF CHILDREN

Phenylzone Paste Caution

Federal (U.S.A.) law restricts this drug to be used by or on the order of a licensed veterinarian.

Each syringe contains 12 g phenylbutazone

Each marking on the plunger contains:

Manufactured for Intervet Inc d/b/a Merck Animal Health

Made in USA

Copyright© 2015 Intervet Inc, a subsidiary of Merck & Co., Inc. Madison, NJ 07940

All rights reserved.

12/15

CPN: 1047147.4