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PenOne Pro Penicillin G Procaine Injection

This page contains information on PenOne Pro Penicillin G Procaine Injection for veterinary use.
The information provided typically includes the following:
  • PenOne Pro Penicillin G Procaine Injection Indications
  • Warnings and cautions for PenOne Pro Penicillin G Procaine Injection
  • Direction and dosage information for PenOne Pro Penicillin G Procaine Injection

PenOne Pro Penicillin G Procaine Injection

This treatment applies to the following species:
Company: VetOne

Sterile Penicillin G Procaine Injectable Suspension U.S.P.

Injectable Antibiotic

Injectable antibiotic in aqueous suspension 300,000 units per ml


NADA 65-010, Approved by FDA

For use in Cattle, Sheep, Swine and Horses.




PenOne Pro™ is a suspension of penicillin G procaine in 100, 250 and 500 mL multiple dose vials. Each mL is designed to provide 300,000 units penicillin G as procaine in a stable suspension. Penicillin G procaine is an antibacterial agent which has activity against a variety of pathogenic organisms, mainly in the Gram-positive category.

Each mL contains 300,000 units Penicillin G Potassium*, 139.0 mg Procaine Hydrochloride*, 2.0% Procaine Hydrochloride, 3.0 mg Potassium Phosphate Monobasic, 6.0 mg Potassium Phosphate Dibasic, 0.4% Sodium Formaldehyde Sulfoxylate, 0.4 mg Polysorbate 80, 2.0 mg Lecithin, 0.1% Methyl Paraben, 0.01% Propyl Paraben, 0.15% Sodium Carboxymethylcellulose, q.s. Water for Injection.

* Penicillin G Potassium and Procaine Hydrochloride react to form penicillin G procaine.

PenOne Pro Penicillin G Procaine Injection Indications

PenOne Pro™ is indicated for treatment of bacterial pneumonia (shipping fever) caused by Pasteurella multocida in cattle and sheep, erysipelas caused by Erysipelothrix insidiosa in swine, and strangles caused by Streptococcus equi in horses.

Directions For Use

A thoroughly cleaned, sterile needle and syringe should be used for each injection (needles and syringes may be sterilized in boiling water for 15 minutes). Before withdrawing the solution from the bottle, disinfect the rubber cap top with 70% alcohol. The injection site should be similarly disinfected with alcohol. Needles of 16 to 18 gauge and 1 to 1.5 inches long are adequate for intramuscular injections.

In livestock, intramuscular injections should be made by directing the needle of suitable gauge and length into the fleshy part of a thick muscle, such as rump, hip, or thigh region; avoid blood vessels and major nerves. Before injecting the solution, pull back gently on the plunger. If blood appears in the syringe, a blood vessel has been entered; withdraw the needle and select a different site.


PenOne Pro™ is administered by the intramuscular route. The product is ready for injection after warming the vial to room temperature and shaking to ensure a uniform suspension.

The daily dose of penicillin is 3,000 units per pound of body weight (1 mL per 100 lbs body weight). Continue daily treatment until recovery is apparent and for at least one day after symptoms disappear, usually in two to three days.

Treatment should not exceed four consecutive days.

No more than 10 mL should be injected at any one site. Rotate injection sites for each succeeding treatment.

Care of Sick Animals:

The use of antibiotics in the management of diseases is based on an accurate diagnosis and an adequate course of treatment. When properly used in the treatment of diseases caused by penicillin-susceptible organisms, most animals treated with PenOne Pro™ show a noticeable improvement within 24 to 48 hours. If improvement does not occur within this period of time, the diagnosis and course of treatment should be re-evaluated. It is recommended that the diagnosis and treatment of animal diseases be carried out by a veterinarian.

Since many diseases look alike but require different types of treatment, the use of professional veterinary and laboratory services can reduce treatment time, costs and needless losses. Good housing, sanitation and nutrition are important in the maintenance of healthy animals and are essential in the treatment of disease.

Residue Warnings:

Exceeding the daily dosage of 3,000 units per pound of body weight, administering for more than four consecutive days, or exceeding the maximum injection site volume per injection site may result in antibiotic residues beyond the withdrawal time. Milk taken from treated dairy animals within 48 hours after the last treatment must not be used for food. Discontinue use of this drug for the following time period before treated animals are slaughtered for food.

Cattle - 14 days, Sheep - 9 days, Swine - 7 days.

A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.


Do not use in horses intended for human consumption. Not for use in humans. Keep out of reach of children.


Intramuscular injection in cattle, sheep, and swine may result in a local tissue reaction which persists beyond the withdrawal period of 14 days (cattle), 9 days (sheep), or 7 days (swine). This may result in trim loss of edible tissue at slaughter.

Allergic or anaphylactic reactions, sometimes fatal, have been known to occur in animals hypersensitive to penicillin and procaine. Such reactions can occur unpredictably with varying intensity. Animals administered penicillin G procaine should be kept under close observation for at least one half hour. Should allergic or anaphylactic reactions occur, discontinue use of the product and call a veterinarian. If respiratory distress is severe, immediate injection of epinephrine or antihistamine following manufacturer’s recommendations may be necessary.

As with all antibiotic preparations, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi. A lack of response by the treated animal, or the development of new signs or symptoms suggest that an overgrowth of nonsusceptible organisms has occurred. In such instances, consult your veterinarian.

It is advisable to avoid giving penicillin in conjunction with bacteriostatic drugs such as tetracyclines.

Storage Conditions:

PenOne Pro™ should be stored between 2 to 8°C (36 to 46°F).

Restricted Drug - California. Use Only as Directed.


Manufactured in the UK.

Norbrook Laboratories Limited, Newry, Northern Ireland

Distributed by: MWI, Boise, ID 83705

(888) 694-8381

Net Contents:




100 mL


V1 501021


250 mL


V1 502021


500 mL


V1 503021


CPN: 13150163

Distributed by MWI Animal Health

3041 W. PASADENA DR., BOISE, ID, 83705
Customer Service:   888-694-8381
Toll-Free:   800-824-3703
Every effort has been made to ensure the accuracy of the PenOne Pro Penicillin G Procaine Injection information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2020 Animalytix LLC. Updated: 2020-10-21