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This page contains information on Nitro-Sal for veterinary use.
The information provided typically includes the following:
  • Nitro-Sal Indications
  • Warnings and cautions for Nitro-Sal
  • Direction and dosage information for Nitro-Sal


This treatment applies to the following species:
Company: Arko



Avirulent Live Culture

20 dose, 50 dose, 100 dose, 500 dose

Nitro-Sal Indications

This product has been shown to be effective for the vaccination of healthy swine 5 weeks of age or older against Salmonella choleraesuis. The duration of immunity has not been determined for this product. For more information regarding efficacy and safety, see

Contact a veterinarian for more information on vaccination frequency. Do not use in pregnant swine.

Use: The product is used at 1 week of age or older by subcutaneous dose of 0.5 ml per pig and by oral route at 5 weeks of age or older.


1. Medications and disinfecting products in the drinking water are not compatible with NITRO-SAL. Discontinue their use at least 3 days before vaccinating and do not resume their use for 3 days following vaccination.

2. Use clean, cool, nonchlorinated water in accordance with the mixing information. Skim milk or an oral vaccine stabilizer should be used in the water line to remove traces of antibacterial agents. Skim milk can be used at 2 cups (480 grams) per gallon of stock solution. Commercial stabilizers should be used according to the directions.

3. Thaw the vaccine just prior to administration at room temperature or lukewarm water. Shake well, remove aluminum cap and seal and use immediately.

4. Dosage is based on the number of pigs to be vaccinated. Use at least one dose per pig to be vaccinated. Add the appropriate amount of vaccine to be delivered to the calculated amount of drinking water directly or in a stock solution to be metered into the water line. The vaccine is supplied in 20, 50, 100 or 500 dose sized vials. Generally, water may be withheld a short time prior to vaccinating to encourage all pigs to drink. Emptying the water line before running vaccine may also help assure delivery of a full dose of vaccine to the end of the water line. The vaccine should be administered orally in an amount of drinking water that would be consumed by thirsty pigs in 4-6 hours. Make sure all vaccine is consumed by the pigs. Provide ample water space so that all the pigs can drink easily.

5. Daily water consumption for each vaccination needs to be determined just prior to use. Water consumption is affected by weather, management conditions and the age of the pigs. When specific water consumption information is not available, please refer to a reference table. The following table will serve as a guideline to determine the amount of water to be used with the vaccine if more specific information is not available.

18 kg or 40 lb. Pigs

4-6 Hour Water Consumption


113.5 L or 30 gal.


227 L or 60 gal.


340.15 L or 90 gal.


454.25 L or 120 gal.


27.75 L or 150 gal.


Store the frozen vaccine at a temperature of 14°F (-10°C). Freezing maximizes the number of organisms preserved and viability at the time of administration.

Trial Data: Store this vaccine at -10° C (14° F) or lower. Use the entire contents when first opened. Inactivate unused contents before disposal. Chlorine or other antimicrobial agents, if present in the vaccine water, may inactivate the vaccine. Use only proper hygiene when handling the vaccine. Clean any spills with disinfectants. Keep the vaccine away from open wounds. Wear gloves if necessary. In case of human exposure, contact a physician. Wash the hands thoroughly after using the vaccine. Do not vaccinate within 21 days of slaughter. Do not mix with other products, except as specified on the label.

ARKO LABORATORIES LTD., Jewell, Iowa 50130


US Veterinary License: 337

PCN: 19A1.00

10 ml

20 Doses

25 ml

50 Doses

50 ml

100 Doses

250 ml

500 Doses

CPN: 1123006.2

P.O. BOX 400, 1336 MAIN STREET, JEWELL, IA, 50130
Telephone:   515-827-5648
Toll-Free:   800-714-2756
Fax:   515-827-5648
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Copyright © 2023 Animalytix LLC. Updated: 2023-05-30