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K9 Advantix II Small Dog

This treatment applies to the following species:
Company: Elanco US

Repels and Kills Ticks, Fleas and Mosquitoes





Biting Flies

Flea Eggs

Flea Larvae


Topical Prevention and Treatment of Fleas, Ticks, Mosquitoes, Biting Flies, and Lice for Monthly Use Only on Dogs and Puppies 7 Weeks of Age and Older and Weighing 4-10 lbs.


For the Prevention and Treatment of Fleas, Ticks, Mosquitoes, Biting Flies and Lice on Dogs

● Repels and kills ticks, fleas and mosquitoes

● Prevents fleas on treated dogs

● Repels and kills ticks, including Deer ticks that may vector Lyme disease and anaplasmosis, American dog ticks that may vector Rocky Mountain spotted fever, tularemia and ehrlichiosis, Brown dog ticks that may vector ehrlichiosis, anaplasmosis, bartonellosis, canine hemoplasmosis, babesiosis and Rocky Mountain spotted fever, and Lone Star ticks that may vector ehrlichiosis and tularemia

● Repels and kills mosquitoes for up to four weeks that may transmit heartworm disease, West Nile Virus

● Kills and repels biting mosquitoes which may cause allergic reactions in your dog such as hives or swelling

● Protect dogs by killing and/or repelling fleas, ticks, mosquitoes, biting flies and lice

● Kills fleas which may cause Flea Allergy Dermatitis and flea bite anemia

● Kills fleas that may cause a tapeworm infection in dogs

● Kills fleas and ticks through contact

● Kills fleas that can transmit tapeworms

● Helps prevent ticks from attaching and feeding on dogs

● Kills and repels ticks on dogs that may cause tick paralysis

Active Ingredients

% By Weight











*cis/trans ratio: Max 55% (±) cis and min 45% (±) trans





● Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye.

● Call a poison control center or doctor for treatment advice.


● Call a poison control center or doctor immediately for treatment advice.

● Have person sip a glass of water if able to swallow.

● Do not induce vomiting unless told to do so by the poison control center or doctor.

● Do not give anything by mouth to an unconscious person.


● Take off contaminated clothing.

● Rinse skin immediately with plenty of water for 15-20 minutes.

● Call a poison control center or doctor for treatment advice.


Have the product container or label with you when calling a poison control center or doctor, or going for treatment. For product questions, to report side effects, or for a copy of the Safety Data Sheet (SDS), call Elanco Product & Veterinary Support at 1-888-545-5973.


Treat the patient symptomatically.

Precautionary Statements

Hazards To Humans


Causes substantial but temporary eye injury. Do not get in eyes or on skin or clothing. Harmful if swallowed. Harmful if absorbed through skin. Avoid contact with skin. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.

Hazards To Domestic Animals

For external use on dogs only. Do not use on animals other than dogs. Do not use on puppies under seven (7) weeks of age or weighing less than 4 lbs. Do not get this product in dog’s eyes or mouth. This product is not a substitute for prescribed heartworm preventative. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing dogs. Individual sensitivities may occur after using ANY pesticide product for dogs. If signs persist, or become more severe, consult a veterinarian immediately. If your dog is on medication, consult your veterinarian before using this or any other product.

Side Effects

Monitor your dog after application. Side effects may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been reported. If these or other side effects (such as lethargy or agitation) occur, consult your veterinarian or call 1-888-545-5973.


Keep cats away from treated dogs for 24 hours.

If applied to a cat or ingested by a cat, contact your veterinarian immediately.

For consumer questions or medical emergencies call 1-888-545-5973.

Environmental Hazards

This pesticide is extremely toxic to aquatic organisms, including fish and invertebrates. Do not add directly to water. Do not contaminate water when disposing of product or packaging.

Directions For Use

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not contaminate feed or food.

Application of product must only be done indoors.


● Do not allow children to apply product.

● Do not have contact or allow children to have contact with treated area until completely dry.

● Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.

● Do not get this product in your dog’s eyes or allow your dog to ingest this product.

● Dogs should be dry prior to application and remain dry for 24 hours after application for product to work effectively.


1. Be sure tube is at bottom of pouch.

2. Using scissors, cut the pouch across the top and remove tube.


1. Remove applicator tube from the package.

2. Dogs should be dry prior to application and remain dry for 24 hours after application.

3. Hold applicator tube in an upright position. Pull cap off tube.

4. Turn the cap around and place other end of cap back on tube.

5. Twist cap to break seal, then remove cap from tube.

6. The dog should be dry and standing for easy application. Evenly apply the entire contents of the K9 Advantix II tube to two to three spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your dog’s eyes, or allow your dog to ingest this product.

7. Discard empty tube as described in Storage and Disposal.

8. In case of severe pest infestation, retreatment is allowable after the initial application earlier than (4) four weeks. Do not retreat more often than once every seven (7) days not to exceed 4 weekly treatments. After pest control is attained, return to a monthly retreatment schedule.

Product Information

The successive feeding activity of fleas on dogs may elicit a hypersensitivity skin disorder known as flea allergy dermatitis (FAD). Treatment of dogs with K9 Advantix II kills fleas and may reduce the incidence of this condition.

K9 Advantix II kills existing fleas on dogs after initial application within 12 hours. Reinfesting fleas are killed within 2 hours with protection against further flea infestation lasting at least four (4) weeks. Pre-existing pupae in the environment may continue to emerge for six (6) weeks or longer depending upon the climatic conditions.

K9 Advantix II is waterproof after 24 hours and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight.

To successfully prevent and control fleas and ticks, all dogs must be treated with their own dose of K9 Advantix II.

Apply according to label instructions, ensuring that the product is applied to the skin, not on top of the fur.

If your dog wears a decorative collar, it may be helpful to remove the collar before application, so it doesn’t absorb the product.

Remember, your dog needs to be dry at the time K9 Advantix II is applied and remains dry 24 hours after application.

Even indoor dogs need protection against fleas and ticks because you or other pets in the household may bring fleas and ticks into the home. Fleas in your dog’s environment can reinfest your dog. If you have a flea infestation, consider treating your home and yard with appropriate premise products to protect against fleas.

Monthly treatments are required for optimal control and prevention of fleas and ticks.


Do not contaminate water, food or feed by storage or disposal.

Pesticide Storage: Store in a cool, dry place inaccessible to children and pets. Protect from freezing.

Pesticide Disposal and Container Handling: Nonrefillable container.

If empty: Do not reuse this container. Place in trash or offer for recycling if available.

If partly filled: Do not pour or dispose down-the- drain. Call your local solid waste agency or 1-888-545-5973 for disposal instructions. Never place unused product down any indoor or outdoor drain.

Limited Warranty And Limitation Of Damages

Elanco US Inc warrants that this material conforms to the chemical description on the label. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ELANCO MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY, INCLUDING ANY OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR MERCHANTABILITY, and no agent of Elanco is authorized to do so except in writing with a specific reference to this warranty. To the extent consistent with applicable law, any damages arising from a breach of this warranty shall be limited to direct damages and shall not include consequential commercial damages such as loss of profits or values, etc.

For additional information visit

Manufactured For:

Elanco US Inc 2500 Innovation Way, Greenfield, IN 46140

K9 Advantix II, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.

August 2022

Patent information at

© 2022 Elanco or its affiliates.

Made in Germany

EPA Est. No. 11556-DEU-1

EPA Reg. No. 11556-141


Net Contents:



1 Tube each 0.014 fl. oz. (0.4 mL)

1 monthly dose


2 Tubes each 0.014 fl. oz. (0.4 mL)

2 monthly doses


3 Tubes each 0.014 fl. oz. (0.4 mL)

3 monthly doses


4 Tubes each 0.014 fl. oz. (0.4 mL)

4 monthly doses


6 Tubes each 0.014 fl. oz. (0.4 mL)

6 monthly doses


CPN: 1131182.0

Customer Service:   317-276-1262
Technical Service:   800-428-4441
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Copyright © 2024 Animalytix LLC. Updated: 2024-02-27