K-Caps 25This page contains information on K-Caps 25 for veterinary use.
The information provided typically includes the following:
- K-Caps 25 Indications
- Warnings and cautions for K-Caps 25
- Direction and dosage information for K-Caps 25
K-Caps 25This treatment applies to the following species:
For use in dogs and cats
KEEP OUT OF THE REACH OF CHILDREN
Each oral capsule contains 25 mg of Phytonadione
Vitamin K1 Capsules contain phytonadione with excipients in an artificially colored soft gelatin shell.
Vitamin K1 Capsules for oral administration possess the same type and degree of activity as does naturally occurring vitamin K. The primary function of vitamin K is to stimulate the production via the liver of active prothrombin from a precursor protein. The mechanism by which vitamin K promotes formation of prothrombin at the molecular level has not been established.
K-Caps 25 Indications
Vitamin K1 Capsules are indicated in dogs and cats to counter hypoprothrombinemia induced by ingestion of coumarin-based compounds, common ingredients of commercial rodenticides, and other drug induced hypoprothrombinemia where it is definitely shown that the result is due to interference with vitamin K metabolism. e.g. salicylates.
Regular determinations of prothrombin time response should be performed to guide in the initial and subsequent administration of Vitamin K1 oral capsules. The dosage should be adjusted accordingly.
Hypersensitivity to any component of this medication.
It is recommended that Vitamin K1 oral capsules be used in follow-up therapy only after administration of Vitamin K1 Injection and hospitalization is no longer required. An immediate coagulant effect should not be expected after administration of phytonadione when administered orally.
Phytonadione will not counteract the anticoagulant action of heparin.
Repeated large doses of Vitamin K1 are warranted in hepatic disease if the response to the initial therapy is unsatisfactory. Failure to respond to Vitamin K1 may indicate that the condition being treated is inherently unresponsive to Vitamin K1.
Protect from light at all times. Temporary resistance to prothrombin-depressing anticoagulants may result, especially when larger doses of phytonadione are used.
Dosage and Administration
Dogs and Cats
Hypoprothrombinemia (with hemorrhage) - Administer orally at the rate of 2.5-5 mg/kg body weight (1 capsule per each 22 pounds of body weight for lower dosage or 1 capsule per each 11 pounds body weight for higher dosage) daily as conditions require up to 3 weeks. Frequency and amount of oral administration should be guided by regular determination of prothrombin time.
The smallest effective dose should be sought to minimize the risk of adverse reaction.
K-Caps 25 Caution
K - CAPS 25 capsules are sold only to licensed veterinarians.
How SuppliedVitamin K1 oral capsules are available in bottles of 50 capsules each.
StorageStore at room temperature (59°- 77° F).
HENRY SCHEIN® ANIMAL HEALTH, 400 Metro Place North, Dublin, OH 43017
Questions? (855) 724-3461
Distributed by: Henry Schein Animal Health, Dublin, OH 43017
Manufactured by: Jice Pharmaceuticals, 6895 Belding Rd., Belding, MI 48809
400 METRO PLACE NORTH, DUBLIN, OH, 43017-7545
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