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Hyvisc (hyaluronate sodium) Injection

This page contains information on Hyvisc (hyaluronate sodium) Injection for veterinary use.
The information provided typically includes the following:
  • Hyvisc (hyaluronate sodium) Injection Indications
  • Warnings and cautions for Hyvisc (hyaluronate sodium) Injection
  • Direction and dosage information for Hyvisc (hyaluronate sodium) Injection

Hyvisc (hyaluronate sodium) Injection

This treatment applies to the following species:
Company: Boehringer Ingelheim Animal Health

(hyaluronate sodium)

Approved by FDA under NADA #122-578

Sterile Injection, 11 mg/mL

For intra-articular injection in horses only

Hyvisc (hyaluronate sodium) Injection Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.


Hyvisc® (hyaluronate sodium) Injection is a clear, colorless, viscous fluid contained in a 5 mL disposable syringe, as a single 2 mL dose. Chemically, hyaluronic acid is a high molecular weight mucopolysaccharide composed of repeating disaccharide units, each unit consisting of D-glucuronic acid and N-acetyl-D-glucosamine. Each mL of Hyvisc Injection contains 11 mg of hyaluronate sodium and 8.47 mg of sodium chloride, USP, in sterile water for injection, USP, q.s.

Actions: Hyaluronate sodium is a natural constituent of connective tissue and synovial fluid in both man and animals. In synovial fluid, hyaluronate sodium confers viscoelastic as well as lubricating properties1,2. In connective tissue, hyaluronate sodium specifically interacts with cartilage proteoglycans to form stable aggregates3,4,5. The mechanism of action by which exogenous hyaluronate sodium exerts its therapeutic effect in arthritic joints is not known at this time.

Hyvisc (hyaluronate sodium) Injection Indications

Hyvisc (hyaluronate sodium) Injection is recommended for the treatment of joint dysfunction in horses due to non-infectious synovitis associated with equine osteoarthritis.

Dosage and Administration

The recommended dose of Hyvisc (hyaluronate sodium) Injection is 2 mL (22 mg) given to horses intra-articularly in small and medium-sized joints (carpal, fetlock). In larger joints (hock), the dosage is 4 mL (44 mg). Treatment may be repeated at weekly intervals for a total of three treatments. As with any intra-articular injection, aseptic technique is used. The following are suggested use directions regardless of the type of joint to be treated.

1. Carefully diagnose each case using routine methods. The origin of lameness should be pinpointed to be within a specific joint or joints (e.g., lameness is localized to a specific joint using intra-articular anesthesia). Radiographs or other diagnostic aids should not reveal recent fractures or other serious abnormalities which would suggest a poor prognosis.

2. Aseptically remove as much synovial fluid from the afflicted joint as can be easily withdrawn.

3. Remove tip cap from the Hyvisc syringe and inject through a sterile needle, 20 gauge or larger.

4. Inject a single 2 mL dose (one syringe) of Hyvisc into each joint to be treated; if the joint being treated is the hock joint, inject 4 mL (two syringes). Since Hyvisc is a viscous fluid, care should be exercised on injection so as not to dislodge the needle from the syringe.

5. Two or four days of rest or light exercise is recommended before resumption of normal activity. Improvement of joint function should be seen within one to two weeks after Hyvisc Injection.

Note: Anika’s syringe system containing the Hyvisc product is designed to be under vacuum until use. Until the vacuum is released through the removal of the tip cap by the end user, the force required to pull back the stopper will result in the plunger rod being pulled out due to excessive force. Inserting the Hyvisc syringe into a vial or bottle that is under vacuum will create a similar result causing the plunger rod to pull away from the stopper.

As with any intra-articular injection, a mild inflammatory response (tenderness, heat and swelling) may be seen in the joint following the Hyvisc Injection. This response is self-limiting, but may last from two to five days after treatment. If inflammation is excessive or severe, the possibility of infection should be considered and appropriate antibiotic therapy instituted.


There are no known contraindications to the use of Hyvisc (hyaluronate sodium) Injection.


Do not use in horses intended for human consumption. Hyvisc (hyaluronate sodium) Injection must not be administered intravascularly.


Used or partially used syringes should be crushed and disposed of in an appropriate landfill.

Do not use if numerous small air bubbles are present throughout the solution.

Adverse Reactions

In the clinical trial with Hyvisc (hyaluronate sodium) Injection, a mild, transient post-injection inflammatory response in the joint was reported in 12% of the cases treated. There were no other side effects.

Safety Margin in Horses: In toxicity studies of Hyvisc (hyaluronate sodium) Injection in horses, intra-articular doses at one, three, and five times the recommended dose once weekly for three consecutive weeks did not result in any drug related local or systemic toxic effects. The mild, transient post-injection inflammatory response observed within the joints of some horses was qualitatively and quantitatively similar to that detected in the physiologic saline injected controls. In a reproductive study in mares, 16 mL of Hyvisc (10 mg/mL) injected intramuscularly or subcutaneously once or twice during the second or third stage of pregnancy resulted in no adverse effects on the mares or newborn foals.


Store under refrigerated conditions, 2° - 8°C (36° - 46°F). Protect from freezing and avoid excessive heat.

How Supplied

Hyvisc (hyaluronate sodium) Injection, 11 mg/mL, is available in 2 mL prefilled, disposable syringes individually packaged.


1. Radin, E.L. et al: Annals of the Rheumatic Diseases, 30: 322-325, (1971).

2. Swann, D.A. et al: Annals of the Rheumatic Diseases, 33: 318-326, (1974).

3. Hardingham, T.E. and H. Muir: Biochemical et Biophysica Acta, 279: 401-405, (1972).

4. Hascall, V.C. and D. Heingard: Journal of Biological Chemistry, 249: 423-433, (1974).

5. Brandt, K.D. et al: Arthritis and Rheumatism, 19: 1308-1314, (1976).

Hyvisc® is a registered trademark of Anika Therapeutics, Inc.

Manufactured by:

Anika Therapeutics, Inc., Bedford, MA 01730 U.S.A.

Distributed by:

Boehringer Ingelheim Animal Health USA Inc., Duluth, GA 30096


AML 520-202/C

Revised 11/2019

© Anika Therapeutics, Inc. 2019


CPN: 1028061.4

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