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Enterisol Salmonella T/C (Canada)

This page contains information on Enterisol Salmonella T/C for veterinary use.
The information provided typically includes the following:
  • Enterisol Salmonella T/C Indications
  • Warnings and cautions for Enterisol Salmonella T/C
  • Direction and dosage information for Enterisol Salmonella T/C

Enterisol Salmonella T/C

This treatment applies to the following species:
Manufacturer: Boehringer

Salmonella Choleraesuis-Typhimurium Vaccine

Avirulent Live Culture

For use in swine only

Enterisol Salmonella T/C Indications

For vaccination of healthy, susceptible swine 2 weeks of age or older as an aid in the prevention of diseases caused by Salmonella choleraesuis and S. typhimurium when administered by individual oral dose or in water. Onset of immunity is evident within 14 days of vaccination for the S. typhimurium fraction.

Directions

Rehydrate the vaccine by adding the full contents of the accompanying sterile diluent to the vaccine vial. Mix gently until contents are completely dissolved. Use entire contents immediately. Rehydrate only with the diluent provided; do not mix with other materials.

Vaccination By Oral Drenching

Administer a single 2 mL dose orally.

Vaccination Via The Drinking Water

Directions For Automatic Watering Systems Equipped With Proportioner

Several types of medicators/proportioners are commercially available.

1. Do not reconstitute the vaccine until ready to vaccinate.

2. Remove all medications, sanitizers, and disinfectants from drinking water, and any medicated feeds, for a minimum of 72 hours (3 days) prior to and following vaccination. This will result in a medication-free vaccination window totaling no less than 7 days in length.

3. Provide sufficient watering space so that all pigs can drink within a 6 hour time frame.

4. Flush watering system with nontreated, clean water to eliminate any antibacterial agents. (This can be accomplished during pre-measurement of stock solution volume requirement in step 6.)

5. Set proportioner to deliver 30 mL of vaccine solution per 3.8 litres of drinking water. Regularly clean proportioners internally to remove antibiotics or other contaminants that may impair vaccine viability. Maintain proportioners to manufacturer’s specifications in order to safeguard accurate vaccine administration.

6. Pre-measure the volume of stock solution required for vaccination during a 6 hour period as follows:

a. Fill a clean bucket or other suitable fluid container with water. Be sure to start with more water than the group of swine is expected to consume in a 6 hour period.

b. Insert proportioner draw tube into the water and ensure that the inlet end rests on the bottom of the container.

c. Adjust valves to start proportioned water flowing into the group of swine scheduled for vaccination.

d. After 6 hours, record the volume of water drawn from the container during this period. This 6 hour disappearance volume will be the total volume of clean water, chlorine neutralizer (step 7c), and vaccine to be used on the day of vaccination.

e. Return water supply flow to normal (bypass the proportioner) until ready to vaccinate.

f. NOTE: it is recommended to conduct this pre-measurement at the same time of day as intended for vaccination.

7. Prepare vaccine stock solution as follows:

a. Reconstitute vaccine according to directions above.

b. Add approximately half of the pre-measured amount of clean, disinfectant-free water to the container to be used for stock solution.

c. To ensure vaccine viability, use a Reload Pack® DT. Add 1 Reload Pack for every 3.8 L of stock solution. Reload Packs contain the stabilizer sodium thiosulfate to neutralize chlorine. A blue dye is also included to facilitate charging water lines (step 8). Mix the water and Reload Pack thoroughly.

d. Add a number of vaccine doses to the stock solution equal to or greater than the number of pigs to vaccinate. Mix thoroughly.

e. Add clean, disinfectant-free water to bring the total volume of this stock solution to the pre-measured 6 hour volume. Mix thoroughly.

8. Vaccinate pigs using the prepared stock-solution as follows:

a. Insert proportioner draw tube into the vaccine stock solution. Ensure that the inlet end is resting on the bottom of the solution container.

b. Adjust water supply valves to direct water through the proportioner.

c. Charge the main water distribution lines throughout the facility being vaccinated. To do this, drain (bleed) water from the valve or drinker on each main line at the end farthest away from the proportioner.

d. Drain water from each main line until the water appears light blue in color.

e. Pigs should consume the vaccine-containing water within 6 hours after reconstituting the vaccine. Do not medicate or use disinfectants immediately following vaccination.

Conventional water directions (open trough or barrel type [tank] system)

1. Do not reconstitute the vaccine until ready to vaccinate.

2. Remove all medications, sanitizers, and disinfectants from drinking water, and any medicated feeds, for a minimum of 72 hours (3 days) prior to and following vaccination. This will result in a medication-free vaccination window totaling no less than 7 days in length.

3. Flush watering system with nonchlorinated/nontreated clean water to eliminate any antibacterial agents.

4. Reconstitute vaccine according to directions above.

5. Add number of doses of vaccine equal to or more than the number of pigs to vaccinate, to the appropriate amount of clean, nontreated drinking water (see Caution section).

6. Final solution containing vaccine should be consumed within 6 hours after reconstitution of the vaccine.

Enterisol Salmonella T/C Caution

The actual amount of water consumed may vary considerably depending on several factors, including environmental temperature and drinker type. It is recommended to pre-measure the actual stock solution volume requirements the day prior to vaccination, during the planned vaccination time period. This should be done in order to ensure that the vaccine is consumed within the 6 hour recommended time frame.

Incompatibility

All materials used in administration of this vaccine must be free of antibiotic and disinfectant residue to prevent vaccine inactivation and reduced product efficacy. A 7-day minimum medication-free period (including feed and water antibiotics) is required (3 days pre-vaccination through 3 days post-vaccination). If possible, a longer medication-free period is recommended.

Precautions

Store at 2-7°C. Do not freeze. Use entire contents immediately. Vaccinated pigs are not to be harvested for human consumption within 21 days after vaccination. Burn container and all unused contents. Anaphylactic reactions may occur. Antidote: Epinephrine. Vaccinated pigs may intermittently shed the vaccine organism in feces for a minimum of 4 weeks after vaccination.

There are no known safety risks to humans, but workers should use protective equipment (gloves, mask) while handling the vaccine during administration and while handling farm wastes. Measures to prevent accidental exposure of immunocompromised or vulnerable individuals should be taken. Municipal and provincial regulations, as well as current Best Management Practices, should be strictly followed for appropriate disposal of the waste from vaccinated pigs.

Enterisol Salmonella T/C® is a registered trademark of Boehringer Ingelheim Vetmedica GmbH. Used under license.

Reload Pack® is a registered trademark of Boehringer Ingelheim Vetmedica, Inc. Used under license.

Manufactured by Boehringer Ingelheim Vetmedica, Inc., St. Joseph, Missouri 64506 U.S.A.

US Vet. Lic. No. 124

Manufactured for Boehringer Ingelheim (Canada) Ltd., Burlington, Ontario L7L 5H4

175710-00

Presentation: 100 doses (200 mL).

CPN: 1230151.0

BOEHRINGER INGELHEIM (CANADA) LTD.
5180 SOUTH SERVICE ROAD, BURLINGTON, ON, L7L 5H4
Customer Care No.:   1-800-567-1885
Technical Services No.:   1-877-565-5501
Website:   www.boehringer-ingelheim.ca
Every effort has been made to ensure the accuracy of the Enterisol Salmonella T/C information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2018 North American Compendiums. Updated: 2018-09-03

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