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Denestra S-Adenosylmethionine (SAMe) 100 mg

This page contains information on Denestra S-Adenosylmethionine (SAMe) 100 mg for veterinary use.
The information provided typically includes the following:
  • Denestra S-Adenosylmethionine (SAMe) 100 mg Indications
  • Warnings and cautions for Denestra S-Adenosylmethionine (SAMe) 100 mg
  • Direction and dosage information for Denestra S-Adenosylmethionine (SAMe) 100 mg

Denestra S-Adenosylmethionine (SAMe) 100 mg

This treatment applies to the following species:
Company: PHS

Denestra® with SAMe supports liver metabolic activity and proper liver function for dogs and cats. SAMe, or S-Adenosyl-Methionine, is a naturally occurring substance found in all living beings. SAMe in its biological form contributes to better pet health through a number of chemical processes: transmethylation, trassulfuration, and aminopropylation. These processes can affect liver and joint health in animals. Through the process of transsulfuration, natural SAMe is converted into a compound called glutathione, a potent antioxidant and liver detoxification tool. It supports normal detoxification and cleansing of the liver from impurities, which in turn may help the body from exposure to heavy metal or environmental toxins. Denestra with naturally occurring SAMe has added benefits for pet joint health as well. During the aminopropylation process, methylthioadenosine (MTA) is produced. MTA helps support cartilage matrix production in the joints, and may help maintain the effectiveness of proteoglycans, molecules that are critical for the lubrication of joints.

Denesta with SAMe is a pill that you administer orally to your dog or cat or may administer in a pill pocket to guarantee it is swallowed. With just one pill you can give your pet support for healthy normal liver and joint function at the same time. It can be used with prescription drugs.

Product Facts

Active Ingredients

per (Tablet):

S-Adenosylmethionine (SAMe) tosylate disulfate (yields S-Adenosylmethionine 50 mg)

100 mg

Inactive Ingredients

Cellulose, Citric Acid, Glycolate, Mannitol, Modified Cellulose Gum, Sodium Starch Silica, and Stearic Acid. (Coating Ingredients: Hydroxypropyl Methylcellulose Phthalate or Methacrylic Acid Copolymer and Hydroxypropyl Methylcellulose; Triacetin, and Titanium Dioxide.)

For Use In:

Dogs and Cats


Denestra should be swallowed and administrated on an empty stomach, one hour before or two hours after a meal (overnight fast is preferred). Do not cut or crush tablets. May be disguised in pill pockets for easier administration.

Maintenance Administration:

Dosage may be increased or decreased at any time at the recommendation of your Veterinarian.


Size of Animal


Under 15 lb

1 Tablet

15 - 35 lb

2 Tablets


Safe use in pregnant animals or animals intended for breeding has not been proven. If animal’s condition worsens or does not improve, stop product administration and consult your veterinarian. Caution in use with antidepressants.

Store in a cool dry place. Keep container at room temperature (59°F-86°F). Keep tablets in their original blister pack until used. Tablets are sensitive to moisture and extreme heat.


For animal use only. Keep out of the reach of children and animals. In case of accidental overdose, contact a health professional immediately.

Product Website:

This product has met all of the stringent quality and safety standards set by the NASC. The NASC (National Animal Supplement Council) is a non-profit self regulatory group that set specific guidelines to which manufactures must strictly adhere.

Those products that have the seal for NASC Quality and Safety standards have been strictly audited and were determined as meeting the following criteria:

● Consistent manufacturing quality control

● A system for evaluating complaints and adverse events

● Clear and accurate labels compliant with codes and restrictions for all forms of labeling

PHS Pet Health Solutions

Distributed by PHS, Inc., 1684 Decoto Road, Suite 200, Union City, CA 94587

60 Tablets 100 mg (60 Doses)


CPN: 6210057.0

34501 7TH ST., UNION CITY, CA, 94587
Toll-Free:   877-564-6862
This service and data are provided "AS IS". DVMetrics and assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics and services and data. See the terms of use for further details.

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