Skip to Content

Compudose Implants (Canada)

This page contains information on Compudose Implants for veterinary use.
The information provided typically includes the following:
  • Compudose Implants Indications
  • Warnings and cautions for Compudose Implants
  • Direction and dosage information for Compudose Implants

Compudose Implants

This treatment applies to the following species:
Manufacturer: Elanco


Controlled Release Implant

DIN 00590932


Active Ingredient

Each implant contains 25.7 mg estradiol impregnated in silicone rubber coated with not less than 0.5 mg oxytetracycline as a local antibacterial.

For subcutaneous ear implantation in beef cattle only.

Compudose Implants Indications

1. For increased rate of weight gain in suckling and growing steers greater than 80 kg (175 lb) body weight.

2. For increased rate of weight gain and improved feed efficiency in feedlot steers and heifers greater than 260 kg (575 lb) body weight.

For maximum response while on pasture, excellent nutrition must be provided by the pasture alone or with grain supplementation.

USE: Each Compudose controlled release implant will provide an effective daily dose of estradiol for at least 200 days.

Directions For Use

Insert one implant under the skin of the ear as directed in this leaflet.


1. Do not use in calves to be processed for veal.

2. Implant Compudose in the ear only; any other location may result in condemnation of the carcass. Do not attempt to salvage the implanted ear for human or animal food.


EQUIPMENT: A Compudose Implanter must be used. Implants and replacement needles are available from your Compudose supplier.

Directions For Implantation

Insert one implant under the skin of the ear.

1. Immobilize the animal in a squeeze chute or by other means.

2. To reduce the possibility of infection, and resulting implant loss, hygienic and antiseptic procedures should be followed during implantation. The ear should be clean and dry. The skin should be cleansed with a suitable antiseptic soap and dried prior to implanting. This is particularly important if the ears are wet or contaminated with urine or feces.

3. To load the Compudose Implanter, remove the cartridge from the package, release the latch on the magazine, open and insert the cartridge. (Figure 1)

Close the magazine and latch. Advance the cartridge to the next implant by inserting the thumb into the magazine opening and turning the cartridge to the next stop.

Use a sharp needle. The needle should be cleaned and sterilized between each injection by wiping the exterior with a sponge, cloth, or gauze saturated with an appropriate disinfectant. The presence of excessive moisture inside the needle may result in dissolving the oxytetracycline (OTC) from the implant surface and contribute to the accumulation of OTC inside the needle.

4. The implant should be deposited under the skin on the back side of the middle third of the ear. It should be placed between the skin and cartilage, avoiding major blood vessels. Grasping the tip of the ear with one hand and the implanter in the other, penetrate the skin in the outer third of the ear. (Figure 2)


5. Upon penetration, the needle should be fully inserted (Figure 3) between the skin and cartilage, avoiding major blood vessels. Full insertion of the needle is important to maximize implant retention.

6. Pull the needle back as the implant is being deposited by squeezing the lever on the implanter grip. Figure 4 shows the implant in proper position in the middle third of the ear where the skin is tight.

7. After repeated use, sufficient oxytetracycline (OTC) from the implant may accumulate inside the needle to impede implant passage. Periodic removal of the needle from the device and washing it in water will prevent such accumulation. Before reusing, the needle should be disinfected and allowed to dry after shaking vigorously to remove excess water or disinfectant.

CONTRAINDICATION: Animals administered an implant at 260 kg (575 lb) body weight need not be reimplanted.


To maximize implant retention:

A. Fully insert the needle.

B. Deposit the implant in the middle third of the ear where the skin is tight.

C. Do not deposit the implant where the skin is loose in the third of the ear closest to the head.

The needle has been scientifically designed to maximize retention. When it becomes dull, use a new needle. If the needle is resharpened, sharpen only the point.


1. Increased sexual activity (bulling, riding and excitability) has been reported in animals implanted with estradiol implants. Implanted animals should be observed for such signs particularly during the first few days after implanting and animals being excessively ridden (bullers) should be removed to prevent physical injury.

2. Carefully check the ears for implant loss approximately 4 weeks after implantation. If loss occurs, re-implant using the recommended procedures.

3. Failure to follow antiseptic implanting procedures, particularly when the ears are wet or contaminated with fecal material may result in infection and excessive implant loss. Dipping animals in contaminated solutions immediately following implanting may also result in infection and loss of the implants.

4. Vaginal and rectal prolapse have been reported in heifers implanted with anabolic estrogens.

5. Do not use in animals intended for breeding purposes.

Side Effects

High tailheads, udder development and swollen vulvas may occur in cattle treated with anabolic estrogens.

How Supplied

Compudose Implants are supplied in boxes of 100 implants packaged as 5 cartridges of 20 implants each.

Elanco, Compudose and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

ELANCO, Division Eli Lilly Canada Inc., 150 Research Lane, Suite 120, Guelph, Ontario N1G 4T2




5 x 20 Implants


Revised 1-Feb-13

NAC No.: 11840054

Division Eli Lilly Canada Inc.

Telephone:   519-821-0277
Order Desk:   800-773-7603
Fax:   519-821-7831
Elanco Canada Limited Customer Service Telephone:   800-387-6325
Elanco Canada Limited Customer Service Fax:   800-827-5782
Every effort has been made to ensure the accuracy of the Compudose Implants information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2018 North American Compendiums. Updated: 2018-03-29