CIDR 330 (Canada)

progesterone releasing intravaginal insert

Veterinary Use Only

for sheep

DIN 02353881

Description

CIDR^® 330 is an intravaginal progesterone release insert containing the naturally occurring hormone progesterone. Attached to each CIDR 330 intravaginal insert is a nylon tail. Each CIDR 330 intravaginal insert contains 0.35 grams progesterone EP, in molded silicone over a flexible nylon spine. The empirical formula for progesterone is C₂₁H₃₀O₂.

The CIDR 330 intravaginal insert provides an exogenous source of the hormone progesterone during the administration period. Removal of the CIDR 330 intravaginal insert results in a rapid fall of plasma progesterone levels, which results in synchronization of estrus in those animals responding to treatment.

Active Ingredient

Progesterone EP, 0.35 grams per CIDR 330 intravaginal insert.

CIDR 330 Indications

CIDR 330 intravaginal insert is indicated for the induction of estrus in ewes (sheep) during seasonal anestrus*.

*Note: Seasonal anestrus is when ewes do not have regular estrous cycles outside the natural breeding season.

Dosage and Administration

Avoid contact with skin by wearing latex gloves when handling CIDR 330 intravaginal insert.

For use with the CIDR 330 applicator.

Administer one CIDR 330 intravaginal insert into the vagina of each ewe to be treated for 5 days. After insert removal, use standard flock breeding procedures to breed ewes at induced estrus. In ewes responding to treatment, the onset of estrus generally occurs within 1 to 3 days after removal of the CIDR 330 intravaginal insert.

Make sure to have sufficient number of rams to adequately breed all ewes with an induced estrus. Breeds of rams may vary in libido in the non-breeding season. Therefore, a ewe to ram ratio up to 18:1 is recommended for multi-sire situations. For single sire situations, 12:1 for ram lambs and up to 18:1 for yearling rams are recommended.

Insertion:

1. Only use the specially designed CIDR 330 applicator for administration.

2. Restrain ewes appropriately prior to administration.

3. Wash the CIDR 330 applicator in a non-irritating antiseptic solution, and then apply a veterinary obstetrical lubricant to the end of the CIDR 330 applicator. The CIDR 330 applicator should be washed and/or disinfected between animals.

4. Push the flexible tail of the CIDR 330 intravaginal insert into the CIDR 330 applicator taking care to assure the tail is extending upward through the slot of the CIDR 330 applicator and is pointed toward the handle.

5. Fold the wings of the CIDR 330 intravaginal insert to make it longer and continue to advance the insert into the CIDR 330 applicator until it is fully seated with only the tips of the wings protruding from the end of the CIDR 330 applicator (see Figure 1).

6. Lubricate the protruding tips of the wings of the CIDR 330 intravaginal insert with veterinary obstetrical lubricant.

7. Clean the exterior of the vulva with disposable tissue.

8. Open the lips of the vulva and gently place the loaded CIDR 330 applicator through the vulva. The slot in the CIDR 330 applicator should face downwards (see Figure 2).

9. Once the loaded CIDR 330 applicator is past the vulva, slope the CIDR 330 applicator slightly upwards (35 - 45° angle) by lowering the handle, and then forward, without forcing, until the CIDR 330 applicator is fully inserted or resistance is felt (see Figure 3).

10. Squeeze the finger grips within the handle of the CIDR 330 applicator to deposit the CIDR 330 intravaginal insert in the anterior vagina (see Figure 4) and then pull the CIDR 330 applicator backwards to remove it from the vagina.

11. With the CIDR 330 intravaginal insert correctly placed, with the wings open in the anterior portion of the vagina, the tail of the CIDR 330 intravaginal insert should be visible, pointing downward from the vulva of the ewe.

Removal:

1. Remove CIDR 330 intravaginal inserts by pulling, gently but firmly, on the protruding nylon tail.

2. CIDR 330 intravaginal inserts may reverse direction within the vagina; therefore, if the nylon tail of the insert is not visible on the day of removal, check the vagina to determine if an insert is present.

3. Used (removed) CIDR 330 intravaginal inserts should be stored in a sealable container until properly disposed in accordance with any applicable local or provincial regulations.

Note: In a multilocation study conducted in the U.S., retention rates from 90 to 100% were observed in ewes, with an average of 97.3%.

Contraindications

Do not use in ewes with abnormal, immature or infected genital tracts.

Do not use in ewes that have never lambed.

CAUTIONS:

CIDR 330 intravaginal inserts have not been tested in estrous cycling ewes.

Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the CIDR 330 intravaginal insert should be disposed of after a single use. If loss rates are high, re-evaluate insertion technique. Contact a veterinarian if abnormal bloody discharge is observed during treatment. Care must be taken when using the CIDR 330 applicator so as not to damage the vagina. Animals in poor condition resulting from illness or nutritional stress may not respond to this drug.

Warnings

Treated animals must not be slaughtered for use as food at least 1 day after removal of the CIDR 330 intravaginal insert.

Warning for the person administering CIDR 330 intravaginal inserts:

Progesterone is a potent steroid hormone and may cause adverse effects on the reproductive system in cases of high or prolonged exposure.

Pregnant women should avoid using CIDR 330 intravaginal inserts.

The product may cause skin and eye irritation, as well as allergic skin rashes.

Wear latex gloves when handling CIDR 330 intravaginal inserts; insert the device using the applicator.

Wash hands and exposed skin with soap and water after use.

Avoid release to the environment.

Keep out of reach of children.

Adverse Reactions

The following may be noticed:

Clear, cloudy, yellow or bloody mucus on the outside of CIDR 330 intravaginal insert when removed from ewes. The mucus may have an offensive odor. This is a result of mild irritation to the vaginal lining by the presence of the CIDR 330 intravaginal insert, and generally clears between the time of removal and breeding. Such irritation does not affect fertility.

Storage

Store between 15 and 30°C.

PRESENTATION: CIDR 330 intravaginal insert is available in bags of 20 inserts.

Zoetis^® and CIDR are registered trademarks of Zoetis or its licensors.

Zoetis Canada Inc., Kirkland QC H9H 4M7

1533-09-4

39020450-02/23

March 2023

CPN: 1198441.4