ChlorPalm 250 (Canada)This page contains information on ChlorPalm 250 for veterinary use.
The information provided typically includes the following:
- ChlorPalm 250 Indications
- Warnings and cautions for ChlorPalm 250
- Direction and dosage information for ChlorPalm 250
ChlorPalm 250This treatment applies to the following species:
Veterinary Use Only
Chloramphenicol Palmitate Oral Suspension
ACTIVE INGREDIENT PER ML
ChlorPalm 250 Indications
As an aid in the treatment of chloramphenicol susceptible bacterial infections:
Dogs: Pneumonia, tracheo-bronchitis (kennel cough), secondary bacterial invaders in distemper, enteritis, metritis, otitis media, urinary tract infections, leptospirosis, ocular infections.
Cats: Haemobartonellosis, chlamydiosis, secondary bacterial infections associated with panleukopenia, otitis media, enteritis, metritis, ocular infections, urinary tract infections.
Chloramphenicol is a broad-spectrum antibiotic shown to have specific therapeutic activity against a wide variety of organisms. It exerts its bacteriostatic action by inhibiting protein synthesis in susceptible organisms. Complete suppression of the assimilation of ammonia and of the incorporation of amino-acids, particularly glutamic acid, together with an increase in the formation of ribonucleic acid (RNA), leads to an inhibition of bacterial growth.
Chloramphenicol antagonizes the action of antibiotics such as penicillin and streptomycin, which act only on growing cells, but is synergistic to tetracycline, which also acts by inhibiting protein synthesis.
Chloramphenicol achieves maximum serum levels very rapidly following oral administration and diffuses readily into all body tissues, but at different concentrations. The highest concentrations are found in the liver and kidney of dogs indicating that these organs are the main routes of inactivation and excretion for the metabolites. The lungs, spleen, heart and skeletal muscles contain concentrations similar to the blood. It reaches significant concentration in the aqueous and vitreous humors of the eye from the blood. A significant difference from other antibiotics is its marked ability to diffuse into the cerebrospinal fluid. Chloramphenicol diffuses readily into milk, pleural and ascetic fluids and crosses the placenta.
Chloramphenicol is rather rapidly metabolized, mainly by the liver, by conjugation with glucuronic acid. This reaction takes place within 8-12 hours following administration. Approximately 55% of a single daily dose can be recovered from the urine of a treated dog. A small fraction of this is in the form of unchanged chloramphenicol.
Dosage and Administration
SHAKE WELL BEFORE USING.
0.5 to 1 mL (25 to 50 mg) per kg of body weight orally every 6 to 8 hours.
1 mL (50 mg) per kg of body weight orally every 12 hours.
Continue treatment for 48 to 72 hours after the animal has become afebrile or asymptomatic.
CAUTIONS: If no clinical response is observed in 3 to 5 days, discontinue treatment and reconsider diagnosis. If animals are treated with this drug for long periods of time or at very high doses, adequate blood studies should be made in order to detect any dyscrasia that may occur. Administration of chloramphenicol to dogs up to 24 days prior to anesthesia with sodium pentobarbital has been reported to result in prolonged anesthesia. Chlor®Palm 250 should be used with caution in animals with hematologic abnormalities, impaired renal or hepatic function, and in animals receiving anticonvulsant drugs. Chloramphenicol products should not be administered to animals maintained for breeding purposes.
WarningsFederal law prohibits the administration of this preparation to animals that produce food or animals that are intended for consumption as food.
Store between 15°C and 25°C.
Vétoquinol N.-A. Inc., 2000, ch. Georges, Lavaltrie, QC, Canada J5T 3S5
2000, CHEMIN GEORGES, LAVALTRIE, QC, J5T 3S5
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