Art Vax

Company: Intervet/Merck Animal Health

BORDETELLA AVIUM VACCINE

Avirulent Live Culture

DIRECTIONS FOR USE, READ CAREFULLY

ART VAX vaccine is a live bacterial vaccine containing a chemically induced mutant of Bordetella avium which is immunogenic for turkeys when given by spray at one day of age, then in the drinking water at 2 weeks of age.

This product has been shown to be effective for the vaccination of healthy turkeys 1 day of age and 2 weeks of age or older against rhinotracheitis (turkey coryza) caused by Bordetella avium. Duration of immunity has not been established. For more information regarding efficacy and safety data, see productdata.aphis.usda.gov.

When To Vaccinate

Vaccinate by spray at one day of age, then in the drinking water at 2 weeks of age. Historically, revaccination every 4 to 6 weeks was recommended for this product. The need for these boosters has not been established. Contact your veterinarian or manufacturer for more information on revaccination frequency. Good management practices must be followed to reduce exposure of birds to virulent B. avium during the first several weeks of life. Vaccination after infection with a field strain of B. avium is ineffective.

Vaccination Program

The development of a durable, strong protection to this disease depends upon the use of an effective vaccination program as well as many circumstances such as administration techniques, environment and flock health at the time of vaccination. Also, the immune response to one vaccination under field conditions is seldom complete for all animals within a given flock. Even when vaccination is successful, the protection stimulated in individual animals against different diseases may not be life long. Therefore, a program of periodic revaccination may be necessary.

Contraindications

Turkeys must be healthy and free of environmental or physical stress at the time of vaccination. Do not use this vaccine within 10 days before or 10 days after vaccinating turkeys with live virus or other live bacterial vaccines.

Preparation Of The Vaccine

FOR DRINKING WATER OR COARSE SPRAY USE

DO NOT OPEN AND MIX THE VACCINE UNTIL READY TO BEGIN VACCINATION. USE VACCINE IMMEDIATELY AFTER MIXING.

1. Remove the tear-off seal and stopper from the vial containing the lyophilized vaccine.

2. Carefully pour clean, cool, non-chlorinated water into the vaccine vial until the vial is approximately two-thirds full.

3. Insert the rubber stopper and shake vigorously until all material is dissolved.

4. The vaccine is now ready to be applied as per label in accordance with the directions below. For best results, be sure to follow directions carefully!

Coarse Spray Administration

FOR BIRDS ONE DAY OF AGE

Calculate the water volume needed. For example, a machine which dispenses 21 ml to a box of 100 turkeys - total volume for 1,000 doses is 210 ml of non-chlorinated water. For coarse spray in bird houses, follow manufacturer’s direction for the particular spray machine. Add rehydrated vaccine and mix thoroughly.

Drinking Water Administration

FOR BIRDS TWO WEEKS OF AGE OR OLDER

1. Do not use any disinfectants in the drinking water for 48 hours before vaccinating and 24 hours after vaccination.

2. Withhold water from the turkeys until they are thirsty.

3. Calculate the water volume needed so the vaccine will be consumed in approximately 2 hours.

4. Optional: as an aid in preserving the virus, add a vaccine stabilizer to the stock solution or to the tank containing clean, cool, nonchlorinated water. Agitate thoroughly. Follow the manufacturer’s rate of administrations and wait time.

5. Add rehydrated vaccine from vial to the water and mix thoroughly.

6. Turn on tank valve or automatic dosing system.

7. Provide as sole source of drinking water until all vaccine-water solution has been consumed.

Art Vax Caution

1. VACCINATE ONLY HEALTHY BIRDS.

2. All birds should be vaccinated at the same time.

3. Do not medicate turkeys with antibacterial drugs 3 days prior to or 5 days after vaccination.

4. Use entire contents when first opened.

5. Do not vaccinate within 21 days before slaughter.

6. Store at 2° to 8°C (35° to 46°F).

7. Inactivate unused contents before disposal.

8. Do not mix with other products, except as specified on the label.

9. In case of human exposure, contact a physician.

10. FOR ANIMAL USE ONLY.

Records

Keep a record of vaccine type, quantity, serial number, expiration date, and place of purchase; the date and time of vaccination; the number, age, breed, and location of the birds; names of operators performing the vaccination and any observed reactions.

FEDERAL REGULATIONS PROHIBIT THE REPACKAGING OR SALE OF THE CONTENTS OF THIS CARTON IN FRACTIONAL UNITS. DO NOT ACCEPT IF SEAL IS BROKEN.

Intervet Inc. d/b/a Merck Animal Health, Omaha, NE 68103 USA

VLN 165A/PCN 1021.01

1 800 211-3573 (USA)

1 866 683-7838 (CAN)

For patent information:

http://www.merck.com/product/patent/home.html

356071 R4

CPN: 1047006.4