Amoxi-DropThis page contains information on Amoxi-Drop for veterinary use.
The information provided typically includes the following:
- Amoxi-Drop Indications
- Warnings and cautions for Amoxi-Drop
- Direction and dosage information for Amoxi-Drop
Amoxi-DropThis treatment applies to the following species:
For veterinary oral suspension
For use in dogs and cats
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Amoxi-Drop (amoxicillin) is a semisynthetic antibiotic with a broad spectrum of activity. It provides bactericidal activity against a wide range of common gram-positive and gram-negative pathogens. Chemically, it is D(-)-α-amino-p-hydroxybenzyl penicillin trihydrate.
Clinical PharmacologyAmoxi-Drop is stable in the presence of gastric acid and may be given without regard to meals. It is rapidly absorbed after oral administration. It diffuses readily into most body tissues and fluids with the exception of brain and spinal fluid, except when meninges are inflamed. Most of the amoxicillin is excreted unchanged in the urine.
Amoxicillin is similar to ampicillin in its bactericidal action against susceptible organisms. It acts through the inhibition of biosynthesis of cell wall mucopeptide. In vitro and/or in vivo studies have demonstrated the susceptibility of most strains of the following gram-positive and gram-negative bacteria: α- and β-haemolytic streptococci, nonpenicillinase-producing staphylococci, Streptococcus faecalis, Escherichia coli, and Proteus mirabilis. Because it does not resist destruction by penicillinase, it is not effective against penicillinase-producing bacteria, particularly resistant staphylococci. All strains of Pseudomonas and most strains of Klebsiella and Enterobacter are resistant.
Amoxi-Drop Indications And Usage
Dogs: Amoxi-Drop is indicated in the treatment of susceptible strains of the organisms causing the following infections:
Respiratory tract infections (tonsillitis, tracheobronchitis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis.
Genitourinary tract infections (cystitis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis.
Gastrointestinal tract infections (bacterial gastroenteritis) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis.
Bacterial dermatitis due to Staphylococcus aureus, Streptococcus spp., and Proteus mirabilis.
Soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus, Streptococcus spp., E. coli, and Proteus mirabilis.
Cats: Amoxi-Drop is indicated in the treatment of susceptible strains of the organisms causing the following infections:
Upper respiratory tract infections due to Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., Haemophilus spp., E. coli, Pasteurella spp., and Proteus mirabilis.
Genitourinary tract infections (cystitis) due to Staphylococcus aureus, Streptococcus spp., E. coli, Proteus mirabilis, and Corynebacterium spp.
Gastrointestinal tract infections due to E. coli, Proteus spp., Staphylococcus spp., and Streptococcus spp.
Skin and soft tissue infections (abscesses, lacerations, and wounds) due to Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., E. coli, and Pasteurella multocida.
The use of this drug is contraindicated in animals with a history of an allergic reaction to penicillin.
WarningsFor use in dogs and cats only. Not for use in animals which are raised for food production.
Adverse ReactionsAmoxicillin is a semisynthetic penicillin and has the potential for producing allergic reactions. If an allergic reaction occurs, administer epinephrine and/or steroids.
Dosage and Administration
Dogs: The recommended dosage is 5 mg/lb of body weight. Administer twice daily for 5-7 days. Continue for 48 hours after all symptoms have subsided.
Cats: The recommended dosage is 50 mg (5-10 mg/lb). Administer once daily for 5-7 days. Continue for 48 hours after all symptoms have subsided.
Directions for Mixing Oral Suspension: Add required amount of water (see following table) to the bottle and shake vigorously. Each mL of suspension will contain 50 mg of amoxicillin as the trihydrate.
Amount of Water Required for Reconstitution
Note: Any unused portion of the reconstituted suspension must be discarded after 14 days. After mixing, refrigeration preferable, but not required.
Do Not Store Dry Powder at Temperatures Above 25°C (77°F)
How SuppliedAmoxi-Drop is supplied in 15-mL bottles containing 0.75 g and 30-mL bottles containing 1.5 g of amoxicillin activity. When reconstituted with required amount of water, each mL contains 50 mg of amoxicillin as the trihydrate.
NADA #55-085, Approved by FDA
PRODUCT OF SINGAPORE
Distributed by: Zoetis Inc., Kalamazoo, MI 49007
NAC No.: 3690166.3
333 PORTAGE STREET, KALAMAZOO, MI, 49007
|Every effort has been made to ensure the accuracy of the Amoxi-Drop information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.|
Copyright © 2017 North American Compendiums. Updated: 2017-08-31