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Advantage II small dog (Canada)

This page contains information on Advantage II small dog for veterinary use.
The information provided typically includes the following:
  • Advantage II small dog Indications
  • Warnings and cautions for Advantage II small dog
  • Direction and dosage information for Advantage II small dog

Advantage II small dog

This treatment applies to the following species:
Company: Elanco

Flea Adulticide/Larvicide/Ovicide and Lice Adulticide

For Dogs 7 weeks and older weighing up to 4.5 kg

Once-A-Month Topical Flea and Lice Treatment




Do not use on other animals






ACTIVE INGREDIENT: Imidacloprid 9.1% and Pyriproxyfen 0.46%

REG. NO. 27581 P.C.P. ACT

Advantage II small dog provides dual protection against fleas and lice. Advantage II small dog kills 98-100% of the existing fleas on dogs within 1 day after treatment. Protection against further flea infestation can last up to 4 weeks. Retreatment at monthly intervals is required if reinfestation is continuous or if flea control is desired. Fleas, eggs, and larvae are killed following contact with skin debris from an Advantage II small dog pet. Advantage II small dog provides multi-stage flea control effectively breaking all flea life-cycle stages for quick and lasting control of flea populations. Advantage II small dog treats lice infestations on dogs.

Do not shampoo or immerse the animal in water immediately after treatment. The animal can be shampooed, immersed in water or exposed to rain 3 days after treatment. Advantage II small dog retains its ovicidal and larvicidal efficacy up to 4 weeks following a shampoo treatment, swimming or exposure to rain. The adulticidal effect may be shortened by repeated shampooing, water immersion or exposure to rain. Reapplication may be required after such activities.

The successive feeding activity of fleas on pets may elicit a hypersensitivity skin disorder known as flea allergy dermatitis (FAD). Treatment of pets with Advantage II small dog rapidly kills fleas and may reduce the incidence of this condition. For effective flea control, treatment of the pet should be combined with sanitation of any area used by the pet. Vacuum floors, carpets and furniture (discard vacuum bag after use) and wash the pet’s bedding, living quarters and surrounding areas. If pest problems persist, an insecticidal premise treatment may be required. A veterinarian should be consulted when pest infestation continues to be a problem on the pet.


HUMANS: KEEP OUT OF THE REACH OF CHILDREN. Harmful if swallowed, or absorbed through the skin. Causes eye irritation. Do not get in eyes. Avoid contact with skin or clothing. Wear rubber gloves during application of this product. After handling or applying, wash hands (or any other skin that came in contact with the product), with soap and water. Avoid contact with pets until dry.

PETS: Do not use on animals under 7 weeks of age. Care should be taken to prevent exposure of other pets who may be in close physical contact with the treated animal. Individual sensitivities, while rare, may occur after using ANY pesticide product for pets. Smaller animals are more likely to experience an adverse reaction. Observe carefully. If signs persist, or become more severe, consult a veterinarian immediately.

Side Effects: Monitor your dog after application. Side effects may include: skin irritation such as redness or scratching; changes in behaviour such as agitation or lethargy; or gastrointestinal effects such as vomiting or loss of appetite. If these or other side effects occur, consult your veterinarian or Elanco at 1-800-265-5475.


HUMANS: IF IN EYES, hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye.

Call a poison control centre or doctor for treatment advice.

IF SWALLOWED, call a poison control centre or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a poison control centre or doctor. Do not give anything by mouth to an unconscious person.

IF ON SKIN OR CLOTHING, take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control centre or doctor for treatment advice.

PETS: If signs of sensitivity occur, bathe the pet with mild soap and rinse with large amounts of water. If signs continue, consult a veterinarian immediately.

Take container, label or product name and Pest Control Product Registration Number with you when seeking medical or veterinary attention.

TOXICOLOGICAL INFORMATION: Treat the patient symptomatically.

DISPOSAL: Do not reuse empty container. Wrap empty tube and cap in newspaper and dispose in household garbage.


This product contains imidacloprid and pyriproxyfen. Do not apply another pest control product such as a shampoo, collar, or powder that contains imidacloprid or pyriproxyfen to the treated animal after applying Advantage II Small Dog.

Do NOT administer by mouth. For dogs 7 weeks and older weighing up to 4.5 kg. This product is packaged in single dosage tubes. This package contains one to six monthly 0.4 mL dosages. Treat your dog monthly in the manner described below. Do not apply a dosage higher than one 0.4 mL tube at one time. Consult a veterinarian before using on sick, aged, pregnant or nursing animals or animals receiving drug or other pesticide treatment. A veterinarian should be consulted when pest infestation continues to be a problem on the pet. Retreatment at monthly intervals is required if reinfestation is continuous or if flea control is desired.

Use only on dogs. Do not use on other animals.

Do not use on puppies under 7 weeks of age.

Remove one applicator from the package.

Hold applicator tube in upright position. Pull cap off tube.

Turn cap around and place other end of cap back on tube.

Twist cap to break seal, then remove cap from tube.

The dog should be standing for easy application. Part the hair on the dog’s back between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to completely empty the contents directly on the skin. Do not get this product in your pet’s eyes or administer by mouth. Until Advantage II small dog dries, keep pet off furniture and away from hardwood floors.

Discard the empty tube as described in “DISPOSAL”.


Advantage, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.

©2022 Elanco or its affiliates.

CONTENTS: One to Six 0.4 mL Tubes

Elanco Canada Limited, 1919 Minnesota Court, Suite 401, Mississauga, Ontario L5N 0C9



CPN: 1231188.1

Customer Service:   800-265-5475
Fax:   519-821-7831
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Copyright © 2023 Animalytix LLC. Updated: 2023-05-30