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Advantage II Medium Dog (Canada)

This page contains information on Advantage II Medium Dog for veterinary use.
The information provided typically includes the following:
  • Advantage II Medium Dog Indications
  • Warnings and cautions for Advantage II Medium Dog
  • Direction and dosage information for Advantage II Medium Dog

Advantage II Medium Dog

This treatment applies to the following species:
Company: Bayer

Flea Adulticide/Larvicide/Ovicide and Lice Adulticide

For Dogs 7 weeks and older weighing between 4.6 and 11 kg

Once-A-Month Topical Flea and Lice Treatment




Do not use on other animals






GUARANTEE: Imidacloprid 9.1% and Pyriproxyfen 0.46%

REG. NO. 27583 P.C.P. ACT

Advantage® II medium dog provides dual protection against fleas and lice. Advantage® II medium dog kills 98-100% of the existing fleas on dogs within 1 day after treatment. Protection against further flea infestation can last up to 4 weeks. Retreatment at monthly intervals is required if reinfestation is continuous or if flea control is desired. If retreatment becomes necessary earlier than 4 weeks, do not retreat more than once weekly. Fleas, eggs, and larvae are killed following contact with skin debris from an Advantage® II medium dog treated pet. Advantage® II medium dog provides multi-stage flea control effectively breaking all flea life-cycle stages for quick and lasting control of flea populations. Advantage® II medium dog treats lice infestations on dogs.

Do not shampoo or immerse the animal in water immediately after treatment. The animal can be shampooed, immersed in water or exposed to rain 3 days after treatment. Advantage® II medium dog retains its ovicidal and larvicidal efficacy up to 4 weeks following a shampoo treatment, swimming or exposure to rain. The adulticidal effect may be shortened by repeated shampooing, water immersion or exposure to rain. Reapplication may be required after such activities.

The successive feeding activity of fleas on pets may elicit a hypersensitivity skin disorder known as flea allergy dermatitis (FAD). Treatment of pets with Advantage® II medium dog rapidly kills fleas and may reduce the incidence of this condition. For effective flea and lice control, treatment of the pet should be combined with sanitation of any area used by the pet. Vacuum floors, carpets and furniture (discard vacuum bag after use) and wash the pet’s bedding, living quarters and surrounding areas. If pest problems persist, an insecticidal premise treatment may be required. A veterinarian should be consulted when pest infestation continues to be a problem on the pet.


HUMANS: KEEP OUT OF THE REACH OF CHILDREN. Harmful if swallowed, or absorbed through the skin. Causes eye irritation. Do not get in eyes. Avoid contact with skin or clothing. Wear rubber gloves during application of this product. After handling or applying, wash hands (or any other skin that came in contact with the product), with soap and water. Avoid contact with pets until dry.

PETS: Do not use on animals under 7 weeks of age. Care should be taken to prevent exposure of other pets who may be in close physical contact with the treated animal. Individual sensitivities, while rare, may occur after using ANY pesticide product for pets. Smaller animals are more likely to experience an adverse reaction. Observe carefully. If signs persist, or become more severe, consult a veterinarian immediately. Call 1 888-663-5326 (1 888-NO-FLEA6) for assistance regarding Advantage® II medium dog use.


HUMANS: IF IN EYES, hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control centre or doctor for treatment advice.

IF SWALLOWED, call a poison control centre or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a poison control centre or doctor. Do not give anything by mouth to an unconscious person.

IF ON SKIN OR CLOTHING, take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control centre or doctor for treatment advice.

PETS: If signs of sensitivity occur, bathe the pet with mild soap and rinse with large amounts of water. If signs continue, consult a veterinarian immediately.

Take container, label or product name and Pest Control Product Registration Number with you when seeking medical or veterinary attention.

TOXICOLOGICAL INFORMATION: Treat the patient symptomatically.

DISPOSAL: Do not reuse empty container. Wrap empty tube and cap in newspaper and dispose in household garbage.


Do NOT administer by mouth. For dogs 7 weeks and older weighing between 4.6 and 11 kg. This product is packaged in single dosage tubes. This package contains one to six monthly 1.0 mL dosages. Treat your dog monthly in the manner described below. Do not apply a dosage higher than one 1.0 mL tube at one time. Consult a veterinarian before using on sick, aged, pregnant or nursing animals or animals receiving drug or other pesticide treatment. A veterinarian should be consulted when pest infestation continues to be a problem on the pet. Retreatment at monthly intervals is required if reinfestation is continuous or if flea control is desired. If retreatment becomes necessary earlier than 4 weeks, do not retreat more than once weekly.

Use only on dogs. Do not use on other animals.

Do not use on puppies under 7 weeks of age.

Remove one applicator from the package.

Hold applicator tube in upright position. Pull cap off tube.

Turn cap around and place other end of cap back on tube.

Twist cap to break seal, then remove cap from tube.

The dog should be standing for easy application. The entire contents of the Advantage® II medium dog tube should be applied evenly to two or three spots on the top of the back from the shoulder to the base of the tail. At each spot part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to dispense a portion of the solution on the skin. Do not apply an excessive amount of solution at one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your pet’s eyes or administer by mouth. Until Advantage® II medium dog dries, keep pet off furniture and away from hardwood floors.

Discard the empty tube as described in “DISPOSAL”.


® TM see

CONTENTS: One to Six 1.0 mL Tubes

Bayer Inc., 2920 Matheson Blvd East, Mississauga, Ontario L4W 5R6

1 888 663-5326



CPN: 1223054.3

Animal Health (acquired by Elanco Canada Limited)

Telephone:   905-282-5550 or 800-62BAYER (800-622-2937)
Technical Service:   888-663-5326
Technical Services Email:
Order Desk:   800-387-9179
Order Desk Fax:   800-361-3306
Fax:   905-282-5725
Every effort has been made to ensure the accuracy of the Advantage II Medium Dog information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2021 Animalytix LLC. Updated: 2020-12-31