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Advantage II Large Cat/Rabbit (Canada)

This page contains information on Advantage II Large Cat/Rabbit for veterinary use.
The information provided typically includes the following:
  • Advantage II Large Cat/Rabbit Indications
  • Warnings and cautions for Advantage II Large Cat/Rabbit
  • Direction and dosage information for Advantage II Large Cat/Rabbit

Advantage II Large Cat/Rabbit

This treatment applies to the following species:
Company: Bayer

Flea Adulticide/Larvicide/Ovicide

For cats 8 weeks and older weighing over 4 kg

For pet rabbits 4 months and older weighing over 4 kg

Once-A-Month Topical Flea Treatment




Do not use on other animals





ACTIVE INGREDIENT: Imidacloprid 9.1% and Pyriproxyfen 0.46%

REG. NO. 27586 P.C.P. ACT

Advantage® II Large Cat / Rabbit kills 98-100% of the existing fleas on cats and pet rabbits within 1 day after treatment. Protection against further flea infestation can last up to 4 weeks on cats and up to 8 days on pet rabbits.

Retreatment at monthly intervals is required if re-infestation is continuous or if flea control is desired. Fleas, eggs, and larvae are killed following contact with skin debris from an Advantage® II Large Cat / Rabbit treated pet. Advantage® II Large Cat / Rabbit provides multi-stage flea control effectively breaking all flea life-cycle stages for quick and lasting control of flea populations.

Do not shampoo or immerse the animal in water immediately after treatment. The animal can be shampooed, immersed in water or exposed to rain 3 days after treatment. Advantage® II Large Cat / Rabbit retains its ovicidal and larvicidal efficacy for up to 4 weeks on cats and up to 8 days on pet rabbits following a shampoo treatment, swimming or exposure to rain. The adulticidal effect may be shortened by repeated shampooing, water immersion or exposure to rain. Reapplication on cats may be required after such activities. Do not reapply before 4 weeks on pet rabbits.

The successive feeding activity of fleas on pets may elicit a hypersensitivity skin disorder known as flea allergy dermatitis (FAD). Treatment of pets with Advantage® II Large Cat / Rabbit rapidly kills fleas and may reduce the incidence of this condition.

For effective flea control, treatment of the pet should be combined with sanitation of any area used by the pet. Vacuum floors, carpets and furniture (discard vacuum bag after use) and wash the pet’s bedding, living quarters and surrounding areas. If pest problems persist, an insecticidal premise treatment may be required. A veterinarian should be consulted when pest infestation continues to be a problem on the pet.


HUMANS: KEEP OUT OF THE REACH OF CHILDREN. Harmful if swallowed. Causes eye irritation. DO NOT get in eyes. Avoid contact with skin or clothing. Wear rubber gloves during application of this product. After handling or applying, wash hands (or any other skin that came in contact with the product), with soap and water. Avoid contact with pets until dry.

PETS: Do not use on cats under 8 weeks of age or on rabbits under 4 months of age. Care should be taken to prevent exposure of other pets who may be in close physical contact with the treated animal. Sensitivities, may occur after using ANY pesticide product for pets. Smaller animals are more likely to experience an adverse reaction. Observe carefully. If signs persist, or become more severe, consult a veterinarian immediately. Call 1 888-663-5326 (1 888-NO-FLEA6) for assistance regarding Advantage® II Large Cat / Rabbit use.


HUMANS: IF IN EYES, hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control centre or doctor for treatment advice.

IF SWALLOWED, call a poison control centre or doctor immediately for treatment advice. Have

person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a

poison control centre or doctor. Do not give anything by mouth to an unconscious person.

IF ON SKIN OR CLOTHING, take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control centre or doctor for treatment advice.

PETS: If signs of sensitivity occur, bathe the pet with mild soap and rinse with large amounts of water. If signs continue, consult a veterinarian immediately. Take container, label or product name and Pest Control Product Registration Number with you when seeking medical or veterinary attention.

TOXICOLOGICAL INFORMATION: Treat the patient symptomatically.

STORAGE: Store container at room temperature.

DISPOSAL: Wrap empty tube and cap in newspaper and dispose in household garbage.


Do NOT administer by mouth.

This product is packaged in single dosage tubes. This package contains one to six monthly 0.8 mL dosages. Do not apply a dosage higher than one 0.8 mL tube at one time. Treat your cat or pet rabbit monthly in the manner described below. Do not use on other animals.


Use only on cats 8 weeks of age and older weighing over 4 kg. Do not use on cats under 8 weeks of age. Repeat every 4 weeks for continual pest control in situations where there is an ongoing risk of pest infestation. If retreatment becomes necessary earlier than 4 weeks, do not retreat more than once weekly.

Pet Rabbits

Use only on pet rabbits 4 months of age and older weighing over 4 kg. Do not use on pet rabbits under 4 months of age. Repeat every 4 weeks for continual pest control in situations where there is an ongoing risk of pest infestation. Do not retreat earlier than 4 weeks. Do not use on rabbits intended for human consumption.

How to Apply

1. Remove one applicator from the package.

2. Hold applicator tube in upright position. Pull cap off tube.

3. Turn cap around and place other end of cap back on tube.

4. Twist cap to break seal, then remove cap from tube.

5. Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to completely empty the contents directly on the skin. Do not get this product in your pet’s eyes or mouth. The product is bitter tasting and salivation may occur for a short time if the animal licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the animal to lick the product. Do not allow recently treated animals to groom each other.

6. Discard the empty tube as described in “DISPOSAL”.

Consult a veterinarian before using on sick, aged, pregnant or nursing animals or animals receiving drug or other pesticide treatment. A veterinarian should be consulted when pest infestation continues to be a problem on the pet.

Until Advantage® II Large Cat / Rabbit dries, keep pet off furniture and away from hardwood floors.

Retain packaging information for future reference

Advantage® II Large Cat / Rabbit, Bayer and Bayer Cross are registered trademarks of Bayer AG used under license by Bayer Inc.

Contents: One to Six 0.8 mL Tubes

Bayer Inc., 2920 Matheson Blvd East, Mississauga, Ontario L4W 5R6

1 888 663-5326



CPN: 1223062.4

Animal Health

Telephone:   905-282-5550 or 800-62BAYER (800-622-2937)
Technical Service:   888-663-5326
Technical Services Email:
Order Desk:   800-387-9179
Order Desk Fax:   800-361-3306
Fax:   905-282-5725
Every effort has been made to ensure the accuracy of the Advantage II Large Cat/Rabbit information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2019 Animalytix LLC. Updated: 2019-09-30