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Zinbryta Side Effects

Generic Name: daclizumab

Note: This page contains side effects data for the generic drug daclizumab. It is possible that some of the dosage forms included below may not apply to the brand name Zinbryta.

In Summary

Common side effects of Zinbryta include: antibody development and hyperglycemia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to daclizumab: subcutaneous solution

As well as its needed effects, daclizumab (the active ingredient contained in Zinbryta) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking daclizumab, check with your doctor immediately:

More common:
  • Bladder pain
  • blistering, crusting, irritation, itching, or reddening of the skin
  • bloody or cloudy urine
  • body aches or pain
  • cough or hoarseness
  • cracked, dry, or scaly skin
  • difficult, burning, or painful urination
  • difficulty with breathing
  • discouragement
  • ear congestion
  • feeling sad or empty
  • fever or chills
  • frequent urge to urinate
  • headache
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • painful or difficult urination
  • rash
  • runny nose
  • sneezing
  • sore throat
  • swelling
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • trouble concentrating
  • trouble sleeping
  • unusual tiredness or weakness
Less common:
  • Dark urine
  • general feeling of tiredness or weakness
  • itching skin
  • light-colored stools
  • persistent loss of appetite
  • red, scaling, or crusted skin
  • right upper quadrant tenderness
  • stomach pain, continuing
  • vomiting
  • yellow eyes or skin
Rare
  • Thoughts or attempts at killing oneself
  • watery or bloody diarrhea
Incidence not known:
  • Dizziness
  • fast heartbeat
  • hives or welts
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • tightness in the chest

Minor Side Effects

Some daclizumab side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Blemishes on the skin
  • pimples
  • seizures

For Healthcare Professionals

Applies to daclizumab: intravenous solution, subcutaneous solution

Cardiovascular

Common (1% to 10%): Lymphadenopathy, lymphadenitis[Ref]

Dermatologic

Very common (10% or more): Rash (i.e., erythematous rash, exfoliative rash, macular rash, maculopapular rash, papular rash, pruritic rash, rash, vesicular rash) (11%)
Common (1% to 10%): Dermatitis (i.e., allergic dermatitis, atopic dermatitis, bullous dermatitis, dermatitis, exfoliative dermatitis, seborrheic dermatitis, eczema, allergic dermatitis), folliculitis, acne, psoriasis, erythema, pruritus, dry skin
Uncommon (0.1% to 1%): Toxic skin eruption, eczema nummular[Ref]

Gastrointestinal

Common (1% to 10%): Tonsillitis, diarrhea
Frequency not reported: Colitis[Ref]

Hematologic

Common (1% to 10%): Anemia, lymphocyte count decreased[Ref]

Hypersensitivity

Frequency not reported: Anaphylaxis[Ref]

Respiratory

Very common (10% or more): Nasopharyngitis (25%), upper respiratory tract infection (17%)
Common (1% to 10%): Bronchitis, pneumonia, laryngitis, rhinitis[Ref]

Psychiatric

Common (1% to 10%): Depression[Ref]

Other

Common (1% to 10%): Oropharyngeal pain, pyrexia[Ref]

Hepatic

Common (1% to 10%): ALT increased, AST increased, liver function test abnormal, hepatic enzymes increased[Ref]

Immunologic

Common (1% to 10%): Influenza, viral infection[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Zinbryta (daclizumab)." AbbVie US LLC, North Chicago, IL.

It is possible that some side effects of Zinbryta may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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