Zilxi Side Effects
Generic name: minocycline topical
Medically reviewed by Drugs.com. Last updated on Feb 10, 2024.
Note: This document contains side effect information about minocycline topical. Some dosage forms listed on this page may not apply to the brand name Zilxi.
Applies to minocycline topical: topical application foam. Other dosage forms:
Serious side effects of Zilxi
Along with its needed effects, minocycline topical (the active ingredient contained in Zilxi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking minocycline topical:
More common
- Redness, dryness, itching, peeling, or discoloration of the treated skin
Less common
Incidence not known
- Blurred vision
- change in ability to see colors, especially blue or yellow
- fever
- general feeling of discomfort or illness
- headache
- increased sensitivity of the skin to sunlight
- itching or skin rash
- joint or muscle pain
- loss of appetite
- redness or other discoloration of the skin
- severe abdominal or stomach cramps and pain
- severe sunburn
- unusual tiredness or weakness
- vomiting
- watery and severe diarrhea, which may also be bloody
Other side effects of Zilxi
Some side effects of minocycline topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Burning, darkening, dryness, flushing, itching, peeling, redness, or stinging on the skin, especially when used on the face
- raised, dark red, wart-like spots on the skin, especially when used on the face
Less common
- Headache
Incidence not known
- Darkening of the skin, teeth, or gums
- dizziness or lightheadedness
- feeling of constant movement of self or surroundings
- sensation of spinning
For Healthcare Professionals
Applies to minocycline topical: mucous membrane insert, topical foam.
General
Minocycline topical (the active ingredient contained in Zilxi) powder is intended for local application only. Systemic effects from the absorption of small amounts of the drug are unlikely.[Ref]
Other
Other side effects have included headache (9%) and pain (4.3%).[Ref]
Dermatologic
Dermatologic side effects have included stomatitis (6.4%), mouth ulceration (5%), and mucous membrane disorder (3.3%).[Ref]
Gastrointestinal
Gastrointestinal side effects have included dyspepsia (4%).[Ref]
Local
Local side effects have included periodontitis (16.3%), tooth disorder (12.3%), tooth caries (9.9%), dental pain (9.9%), gingivitis (9.2%), pharyngitis (4.3%), and dental infection (3.8%).[Ref]
Immunologic
Immunologic side effects have included flu syndrome (5%) and infection (7.6%).[Ref]
More about Zilxi (minocycline topical)
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References
1. Product Information. Arestin (minocycline topical). OraPharma Inc. 2001;PROD.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.