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Yimmugo Side Effects

Generic name: immune globulin intravenous

Medically reviewed by Drugs.com. Last updated on Jun 19, 2024.

Note: This document provides detailed information about Yimmugo Side Effects associated with immune globulin intravenous. Some dosage forms listed on this page may not apply specifically to the brand name Yimmugo.

Applies to immune globulin intravenous: intravenous solution.

Important warnings This medicine can cause some serious health issues

Intravenous route (solution)

Warning: Thrombosis, Renal Dysfunction, and Acute Renal Failure. Thrombosis may occur with immune globulin intravenous (IGIV) products, including immune globulin-ifas.

Risk factors may include: advanced age, prolonged immobilization, hypercoagulable conditions, history of venous or arterial thrombosis, use of estrogens, indwelling vascular catheters, hyperviscosity, and cardiovascular risk factors.Renal dysfunction, acute renal failure, osmotic nephropathy, and death may occur with the administration of IGIV products in predisposed patients.

Renal dysfunction and acute renal failure occur more commonly in patients receiving IGIV products containing sucrose.

Immune globulin-ifas does not contain sucrose.For patients at risk of thrombosis, renal dysfunction, or renal failure, administer immune globulin-ifas at the minimum infusion rate practicable.

Ensure adequate hydration in patients before administration.

Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk for hyperviscosity.

Precautions

It is very important that your doctor check your progress closely for any problems that may be caused by this medicine. Blood and urine tests may be needed to check for unwanted effects.

This medicine may cause fever, chills, flushing, headaches, nausea, and vomiting, especially if you are receiving it for the first time or if you have not received it for more than 8 weeks. Check with your doctor or nurse right away if you have any of these symptoms.

This medicine is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor if you have concerns about this risk.

This medicine may cause a serious type of allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hives, chest pain, dizziness or lightheadedness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine. Certain people, including those with IgA (an immunoglobulin) deficiency and antibodies against IgA and a history of hypersensitivity to human immunoglobulin products should not use this medicine.

Check with your doctor right away if you start to have a stiff neck, drowsiness, fever, severe headache, nausea, vomiting, painful eye movements, or eye sensitivity to light. These could be symptoms of a serious condition called aseptic meningitis syndrome (AMS).

This medicine may cause bleeding (hemolysis) or hemolytic anemia. Tell your doctor right away if you have stomach or back pain, dark urine, decreased urination, difficulty with breathing, an increased heart rate, tiredness, or yellow eyes or skin after you receive the medicine.

Check with your doctor right away if you start having chest pain, difficult, fast, or noisy breathing, blue lips and fingernails, fever, pale skin, increased sweating, coughing that sometimes produces a pink frothy sputum, or swelling of the legs and ankles after receiving this medicine. These may be symptoms of a serious lung problem.

Check with your doctor right away if you start having red or dark brown urine, lower back or side pain, sudden weight gain, swollen face, arms, or legs, decreased urine output, or any problems with urination after you receive this medicine. These may be symptoms of a serious kidney problem.

Your blood pressure might get too high while you are using this medicine. This may cause headaches, dizziness, or blurred vision. You might need to measure your blood pressure at home. If you think your blood pressure is too high, call your doctor right away.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Yimmugo

Along with its needed effects, immune globulin intravenous (the active ingredient contained in Yimmugo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking immune globulin intravenous:

More common side effects

  • cough
  • cough producing mucus
  • difficulty breathing
  • fever
  • headache
  • pain or tenderness around the eyes and cheekbones
  • pale skin
  • stuffy or runny nose
  • tightness of the chest
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Incidence not known

  • agitation
  • anxiety
  • back pain
  • black, tarry stools
  • blistering, peeling, or loosening of the skin
  • bloody or cloudy urine
  • bloody, black, or tarry stools
  • blue lips and fingernails
  • bluish lips or skin
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in color vision
  • changes in skin color
  • chest pain or discomfort
  • chills
  • confusion
  • coughing that sometimes produces a pink frothy sputum
  • dark urine
  • decreased frequency or amount of urine
  • decreased urination
  • decreased urine output
  • diarrhea
  • difficult or painful urination
  • difficult, fast, noisy breathing
  • difficulty in speaking
  • difficulty seeing at night
  • difficulty swallowing
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • double vision
  • drowsiness
  • fainting
  • fast or irregular heartbeat
  • hallucinations
  • high fever
  • hives, itching, skin rash
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • increased blood pressure
  • increased sensitivity of the eyes to sunlight
  • increased sweating
  • increased thirst
  • irritability
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • loss of appetite loss of consciousness
  • lower back or side pain
  • mood or mental changes
  • muscle pain or cramps
  • nausea
  • nervousness
  • noisy breathing
  • noisy, rattling breathing
  • pain, redness, or swelling in the arm or leg
  • painful or difficult urination
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seizures
  • slow heartbeat
  • slow speech
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiff neck or back
  • stomach pain
  • sudden decrease in the amount of urine
  • swelling of the face, fingers, hands, feet, or lower legs
  • swollen glands
  • tenderness
  • unusual bleeding or bruising
  • unusual drowsiness, dullness, or feeling of sluggishness
  • vomiting
  • weight gain
  • yellow eyes or skin

Other side effects of Yimmugo

Some side effects of immune globulin intravenous may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • blistering, crusting, irritation, itching, or reddening of the skin
  • cracked, dry, scaly skin
  • swelling
  • upper stomach pain

Incidence not known

  • anxiety
  • bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • bone pain
  • difficulty in moving
  • hair loss, thinning of hair
  • joint swelling
  • nervousness

For healthcare professionals

Applies to immune globulin intravenous: intravenous powder for injection, intravenous solution.

General adverse events

The most common adverse events were headache, cough, fatigue, infusion site reaction, nausea, urticaria, sinusitis, blood pressure increased, diarrhea, dizziness, and lethargy.[Ref]

Respiratory

Cardiovascular

Nervous system

Gastrointestinal

Other

Hepatic

Hematologic

Local

Dermatologic

Hypersensitivity

Musculoskeletal

Metabolic

Renal

Psychiatric

Ocular

Immunologic

See also:

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. Cerner Multum, Inc. "Australian Product Information."

3. (2013) "Product Information. Bivigam (immune globulin intravenous)." Biotest Pharmaceuticals Corporation

4. (2016) "Product Information. Gammagard S/D (immune globulin intravenous)." Baxter Healthcare Corporation

5. (2016) "Product Information. Privigen (immune globulin intravenous)." CSL Behring Canada Inc

6. (2016) "Product Information. Flebogamma (immune globulin intravenous)." Grifols USA LLC

Further information

Yimmugo side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.