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Xylon 10 Side Effects

Generic Name: hydrocodone / ibuprofen

Note: This document contains side effect information about hydrocodone / ibuprofen. Some of the dosage forms listed on this page may not apply to the brand name Xylon 10.

In Summary

Common side effects of Xylon 10 include: drowsiness and dyspepsia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hydrocodone / ibuprofen: oral tablet

Along with its needed effects, hydrocodone/ibuprofen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrocodone / ibuprofen:

Less common or rare
  • Bloody stools
  • burning feeling in the chest or stomach
  • congestion in the chest
  • changes in facial skin color
  • cough
  • diarrhea
  • difficulty with swallowing
  • fast or irregular breathing
  • fever
  • frequent urge to urinate
  • heartburn
  • inability to urinate
  • irregular heartbeat
  • lightheadedness or dizziness
  • loss of bladder control
  • puffiness or swelling of the eyelids or around the eyes
  • ringing or buzzing in the ears
  • tightness in the chest
  • troubled breathing
  • skin rash, hives, or itching
  • stomach pain
  • tenderness in the stomach

Get emergency help immediately if any of the following symptoms of overdose occur while taking hydrocodone / ibuprofen:

Symptoms of overdose
  • Blurred vision
  • cold or clammy skin
  • confusion
  • difficulty hearing or ringing or buzzing in the ears
  • dizziness
  • general feeling of illness
  • headache
  • mood or mental changes
  • nausea or vomiting
  • severe drowsiness
  • severe stomach pain
  • skin rash
  • slow heartbeat
  • slow or troubled breathing
  • stiff neck or back
  • swelling of the face, fingers, feet, or lower legs

Some side effects of hydrocodone / ibuprofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Anxiety
  • constipation
  • dry mouth
  • gas
  • increased sweating
  • nervousness
  • pounding heartbeat
  • sleepiness
  • trouble in sleeping
  • unusual tiredness or weakness
Less common or rare
  • Decreased appetite
  • decrease in sexual ability
  • depression
  • headache
  • heartburn
  • increased thirst
  • irritability
  • mood or mental changes
  • mouth ulcers
  • pain or burning in the throat
  • runny nose
  • sensation of burning, warmth, heat, numbness, tightness, or tingling
  • slurred speech
  • stomach upset
  • thinking abnormalities
  • trembling or shaking of the hands or feet
  • unexplained weight loss
  • unusual feeling of well-being
  • visual disturbances

For Healthcare Professionals

Applies to hydrocodone / ibuprofen: oral tablet


The more commonly reported adverse reactions have included headache, dizziness, constipation, and dyspepsia.[Ref]


Dyspnea, hiccups, pharyngitis, and rhinitis have been reported in less than 3% of patients; asthma, bronchitis, hoarseness, increased cough, pulmonary congestion, pneumonia, shallow breathing, and sinusitis in less than 1%.

Frequency not reported: Dyspnea, hiccups, pharyngitis, rhinitis, asthma, bronchitis, hoarseness, increased cough, pulmonary congestion, pneumonia, shallow breathing, sinusitis


Serious gastrointestinal events including upper GI ulcers, gross bleeding, or perforation attributed to NSAID use have occurred in approximately 1% of patients treated for 3 to 6 months, and in about 2% to 4% of patients treated for 1 year.

Very common (10% or more): Constipation (22%), dyspepsia (12%), nausea (21%)
Common (1% to 10%): Abdominal pain, diarrhea, dry mouth, flatulence, vomiting
Frequency not reported: Anorexia, gastritis, melena, mouth ulcers, thirst, chalky stool, clenching teeth, dysphagia, esophageal spasm, esophagitis, gastroenteritis, glossitis

Common (1% to 10%): Serious upper GI events


Arrhythmia, hypotension, and tachycardia have been reported in less than 1% of patients.

NSAID use in post-MI patients has been shown to increase the risk of reinfarction, CV-related death, and all-cause mortality beginning the first week of treatment. NSAID use in the first 10 to 14 days following CABG surgery demonstrated an increased incidence of MI and stroke; NSAIDs are contraindicated in the setting of CABG.

Common (1% to 10%): Palpitations, vasodilation, edema
Frequency not reported: Arrhythmia, hypotension, tachycardia

Common (1% to 10%): Peripheral edema
Uncommon (0.1% to 1%): Hypertension
Frequency not reported: Cardiovascular thrombotic events, myocardial infarction, reinfarction


Common (1% to 10%): Pruritus, sweating
Frequency not reported: Rash, urticaria

Frequency not reported: Exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis


Frequency not reported: Allergic reaction

Postmarketing reports: Anaphylaxis

Postmarketing reports: Anaphylaxis

Nervous system

Very common (10% or more): Headache (27%), dizziness (14%)
Frequency not reported: Hypertonia, paresthesia, somnolence, neuralgia, slurred speech, tremor, bad taste

Postmarketing reports: Serotonin syndrome

Rare (less than 0.1%): Aseptic meningitis

Hypertonia, paresthesia, and somnolence have been reported in less than 3% of patients; neuralgia, bad taste, slurred speech, and tremor in less than 1% of patients.

The incidence of aseptic meningitis associated with ibuprofen is higher in patients with systemic lupus erythematosus and other connective tissue diseases although it has been reported in patients without such underlying disease states.


Very common (10% or more): Transaminase elevations less than 3 times the upper limit of normal (3 x ULN) (15%)
Common (1% to 10%): Transaminase elevations greater than 3 x ULN
Rare (less than 0.1%): Severe hepatic injury including fulminant hepatitis, liver necrosis, and hepatic failure

Elevations in liver function tests 3 x ULN occurred in less than 1% of patients.


Frequency not reported: Mild renal insufficiency as well as nephrotic syndrome with and without renal failure, acute renal failure due to tubulointerstitial nephritis, papillary necrosis, and acute tubular necrosis


Frequency not reported: Decrease weight

Frequency not reported: Hyperkalemia


Common (1% to 10%): Anxiety, insomnia, nervousness
Frequency not reported: Confusion, abnormal thinking, agitation, abnormal dream, decreased libido, depression, euphoria, mood changes
Postmarketing reports:

Confusion and abnormal thinking have been reported in less than 3% of patients; agitation, abnormal dream, decreased libido, depression, euphoria, and mood changes in less than 1%.


Common (1% to 10%): Asthenia,
Frequency not reported: Fever, flu syndrome, tinnitus, vertigo

Fever, flu syndrome, and tinnitus have been reported in less than 3%; vertigo in less than 1%.


Urinary frequency has been reported in less than 3% of patients; cystitis, glycosuria, impotence, urinary incontinence, and urinary retention in less than 1%.

Frequency not reported: Urinary frequency, cystitis, glycosuria, impotence, urinary incontinence, urinary retention


Frequency not reported: Altered vision, dry eyes

Altered vision and dry eyes have been reported in less than 1% of patients.


Common (1% to 10%): Infection


Postmarketing reports: Adrenal insufficiency, androgen deficiency


Pain has been reported in less than 3% of patients; myalgia and arthralgia in less than 1%.

Common (1% to 10%): Pain
Frequency not reported: Myalgia, arthralgia


1. "Product Information. Hydrocodone-Ibuprofen (hydrocodone-ibuprofen)." Par Pharmaceutical Inc (formerly Qualitest Pharmaceuticals Inc), Huntsville, AL.

Some side effects of Xylon 10 may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

More about Xylon 10 (hydrocodone / ibuprofen)

Consumer resources

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Professional resources

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