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Viokace Side Effects

Generic name: pancrelipase

Medically reviewed by Drugs.com. Last updated on Dec 10, 2024.

Note: This document provides detailed information about Viokace Side Effects associated with pancrelipase. Some dosage forms listed on this page may not apply specifically to the brand name Viokace.

Applies to pancrelipase: oral capsule, oral capsule delayed release, oral tablet, oral tablet enteric coated.

Other dosage forms:

Precautions

It is very important that your doctor check the progress of you or your child at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you or your child should continue to take it.

For patients taking the capsules containing the powder:

For patients taking the powder form of this medicine:

Check with your doctor right away if you or your child have unusual or severe abdominal or stomach pain, trouble passing stool, nausea, or vomiting. These may be symptoms of a rare but serious bowel disorder, called fibrosing colonopathy.

This medicine may cause irritation of the inside of your or your child's mouth if it is not swallowed completely, is crushed or chewed, or is mixed into foods that are not recommended. Follow your doctor's instructions carefully to prevent this.

Pancrelipase may increase uric acid levels in the blood. Check with your doctor if you or your child have joint pain, stiffness, or swelling, lower back, side, or stomach pain, or swelling of the feet or lower legs.

This medicine is made from the pancreas of pigs. The risk of getting a virus from medicines made of pig organs has been greatly reduced in recent years. This is the result of required testing for certain viruses, and testing during manufacture of these medicines. Although the risk of transmitting certain viruses to people who will use the medicine is low, talk with your doctor if you or your child have concerns.

This medicine may cause serious types of allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat while you or your child are using this medicine.

Tell your doctor if you have a history of abnormal blood glucose levels before taking Zenpep®.

Common side effects of Viokace

Some side effects of pancrelipase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • blurred vision
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • sweating
  • unexplained weight loss
  • vomiting

Less common side effects

  • abnormal feces
  • anxiety
  • bloated feeling
  • chills
  • cold sweats
  • confusion
  • cool, pale skin
  • depression
  • excess air or gas in the stomach or intestines
  • feeling of fullness
  • fever
  • frequent bowel movements
  • loss of consciousness
  • muscle aches
  • nightmares
  • passing gas
  • runny nose
  • seizures
  • shakiness
  • slurred speech
  • sore throat

Incidence not known

  • difficulty having a bowel movement
  • difficulty with moving
  • muscle aching or cramping
  • muscle pains or stiffness
  • muscle spasm
  • swollen joints

Serious side effects of Viokace

Along with its needed effects, pancrelipase (the active ingredient contained in Viokace) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pancrelipase:

Rare side effects

  • skin rash or hives

With high doses

With very high doses

With powder dosage form or powder from opened capsules

- if breathed in

With tablets

- if held in the mouth

Incidence not known

  • cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • itching
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • severe stomach pain
  • unusual tiredness or weakness

For healthcare professionals

Applies to pancrelipase: oral capsule, oral capsule extended release, oral delayed release capsule, oral powder for reconstitution, oral tablet, oral tablet extended release.

General adverse events

The most commonly reported side effects included gastrointestinal complaints, abdominal pain, and headaches.[Ref]

Gastrointestinal

Bowel stricture formation occasionally occurred in children with cystic fibrosis who received high doses.

Moderate duodenitis and gastritis occurred in a patient with exocrine pancreatic insufficiency due to cystic fibrosis 16 days after completing treatment with 4000 lipase units/gram fat ingested per day for 5 to 6 days, followed by placebo for an additional 5 to 6 days.[Ref]

Nervous system

A dull headache was reported by a patient receiving treatment with ursodeoxycholic acid concomitantly. The event resolved without sequelae after discontinuation of this drug.[Ref]

Metabolic

Hepatic

Hematologic

Respiratory

Other

Dermatologic

Musculoskeletal

Cardiovascular

Oncologic

Psychiatric

Renal

Immunologic

Hypersensitivity

A patient with a known history of allergy to another pancrelipase (the active ingredient contained in Viokace) product developed a mild allergic reaction, including red, blotchy facial rash and itching. The event resolved without sequelae after discontinuation of this drug.[Ref]

Genitourinary

Ocular

See also:

References

1. (2001) "Product Information. Viokase (pancrelipase)." Wyeth-Ayerst Laboratories

2. (2022) "Product Information. Ku-Zyme (pancrelipase)." Schwarz Pharma

3. (2001) "Product Information. Zymase (pancrelipase)." Organon

4. (2001) "Product Information. Cotazym (pancrelipase)." Organon

5. (2001) "Product Information. Cotazym-S (pancrelipase)." Organon

6. (2001) "Product Information. Pancrease (pancrelipase)." McNeil Pharmaceutical

7. (2022) "Product Information. Pancrease (pancrelipase)." Apothecon Inc

8. (2001) "Product Information. Ultrase (pancrelipase)." Scandipharm Inc

9. "Product Information. Ultrase MT 12 (pancrelipase)." Scandipharm Inc

10. (2001) "Product Information. Creon 5 (pancrelipase)." Solvay Pharmaceuticals Inc

11. (2001) "Product Information. Creon 10 (pancrelipase)." Solvay Pharmaceuticals Inc

12. (2001) "Product Information. Creon 20 (pancrelipase)." Solvay Pharmaceuticals Inc

13. Cerner Multum, Inc. "Australian Product Information."

Frequently asked questions

Further information

Viokace side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.