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Pancrelipase use while Breastfeeding

Drugs containing Pancrelipase: Creon, Zenpep, Pancrease, Pertzye, Pancreaze, Viokace, Viokase, Cotazym, Plaretase, Lipram-CR10, Show all 64 »Pangestyme CN 20, Pangestyme EC, Pangestyme UL 18, Pangestyme MT 16, Lipram-UL 12, Pangestyme CN 10, Pancreatil-UL 12, Viokase 16, Lipram-UL 20, Ku-Zyme, Kutrase, Dygase, Lipram-CR, Viokase 8, Lipram-CR5, Lapase, Lipram-UL 18, Pancrecarb MS-16, Pangestyme UL 20, Panocaps, Panocaps MT 16, Palcaps 10, Lipram-PN10, Lipram-PN16, Lipram-PN20, Lipram-CR20, Ultrase MT 18, Pancrecarb MS-4, Lipram UL, Ultresa, Pancrecarb MS, Zymase, Pancrease MT 4, Pancrease MT 16, Protilase, Panase, Ku-Zyme HP, Cotazym-S, Ultrase MT 20, Protilase MT-16, Pancrease MT 10, Pancrecarb MS-8, Vio-Moore, Pancrease MT, Panokase, Ilozyme, Pancrease MT 20, Ultrase, Ultrase MT 12, Pancron D/R, Encron-10, Arco-Lase, Lipram, Panokase 16

Medically reviewed by Last updated on Sep 15, 2020.

Pancrelipase Levels and Effects while Breastfeeding

Summary of Use during Lactation

Pancrelipase has been used in mothers of breastfed infants with apparent allergy to proteins in breastmilk derived from the maternal diet. This technique seems to have improved symptoms of egg allergy and cow’s milk allergy, such as blood in the stool and colic.[1-3] Pancreatic enzymes are not appreciably absorbed from the mother’s gastrointestinal tract, so should not reach the infant. Expert opinion considers use of pancrelipase to be acceptable during breastfeeding.[4,5]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


Des Roches A, Abbott M, Begin P, et al. Oral pancreatic enzyme supplements can reduce excretion of ovalbumin in breast milk. J Investig Allergol Clin Immunol. 2014;24:62–3. [PubMed: 24765885]
Repucci A. Resolution of stool blood in breast-fed infants with maternal ingestion of pancreatic enzymes. J Pediatr Gastroenterol Nutr. 1999;29:500. Abstract.
Schach B, Haight M. Colic and food allergy in the breastfed infant: Is it possible for an exclusively breastfed infant to suffer from food allergy? J Hum Lact. 2002;18:50–2. [PubMed: 11845737]
Middleton PG, Gade EJ, Aguilera C, et al. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020;55:1901208. [PubMed: 31699837]
ABM Clinical Protocol #24. Allergic proctocolitis in the exclusively breastfed infant. Breastfeed Med. 2011;6:435–40. [PubMed: 22050274]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Gastrointestinal Agents


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Further information

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