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Pancrelipase use while Breastfeeding

Medically reviewed by Last updated on Aug 21, 2023.

Drugs containing Pancrelipase: Creon, Zenpep, Pancreaze, Pertzye, Viokace, Lapase, Pancrease, Ultresa, Cotazym, Viokase, Show all 64 »Panase, Pancrease MT 10, Pancrease MT 20, Ultrase, Pancrecarb MS, Zymase, Pancrease MT 4, Pancrease MT 16, Protilase, Ku-Zyme HP, Cotazym-S, Ultrase MT 20, Protilase MT-16, Lipram UL, Vio-Moore, Pancrease MT, Panokase, Ilozyme, Ultrase MT 12, Pancron D/R, Encron-10, Ultrase MT 18, Arco-Lase, Lipram, Pancrecarb MS-8, Pancrecarb MS-4, Lipram-UL 18, Lipram-CR20, Lipram-UL 12, Lipram-UL 20, Viokase 16, Pancreatil-UL 12, Pangestyme CN 10, Pangestyme CN 20, Pangestyme MT 16, Pangestyme UL 18, Pangestyme EC, Kutrase, Ku-Zyme, Lipram-CR, Plaretase, Viokase 8, Lipram-CR5, Dygase, Pancrecarb MS-16, Pangestyme UL 20, Panocaps, Panocaps MT 16, Lipram-CR10, Palcaps 10, Lipram-PN10, Lipram-PN16, Lipram-PN20, Panokase 16

Pancrelipase Levels and Effects while Breastfeeding

Summary of Use during Lactation

Pancrelipase has been used in mothers of breastfed infants with apparent allergy to proteins in breastmilk derived from the maternal diet. This technique seems to have improved symptoms of egg allergy and cow’s milk allergy, such as blood in the stool and colic.[1-3] Pancreatic enzymes are not appreciably absorbed from the mother’s gastrointestinal tract, so they should not reach the infant. Expert opinion considers use of pancrelipase to be acceptable during breastfeeding.[4,5]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


Des Roches A, Abbott M, Begin P, et al. Oral pancreatic enzyme supplements can reduce excretion of ovalbumin in breast milk. J Investig Allergol Clin Immunol 2014;24:62-3. [PubMed: 24765885]
Repucci A. Resolution of stool blood in breast-fed infants with maternal ingestion of pancreatic enzymes J Pediatr Gastroenterol Nutr;29:500. Abstract.
Schach B, Haight M. Colic and food allergy in the breastfed infant: Is it possible for an exclusively breastfed infant to suffer from food allergy? J Hum Lact 2002;18:50-2. [PubMed: 11845737]
Middleton PG, Gade EJ, Aguilera C, et al. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J 2020;55:1901208. [PubMed: 31699837]
ABM Clinical Protocol #24: Allergic proctocolitis in the exclusively breastfed infant. Breastfeed Med 2011;6:435-40. [PubMed: 22050274]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Milk, Human

Gastrointestinal Agents


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Further information

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