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Pancrelipase use while Breastfeeding

Medically reviewed by Drugs.com. Last updated on Feb 12, 2022.

Drugs containing Pancrelipase: Creon, Zenpep, Pancreaze, Viokace, Pertzye, Cotazym, Viokase, Pancrease, Encron-10, Ultresa, Show all 64 »Pancrecarb MS, Zymase, Pancrease MT 4, Pancrease MT 16, Protilase, Panase, Ku-Zyme HP, Cotazym-S, Ultrase MT 20, Protilase MT-16, Lipram UL, Pancrease MT 10, Vio-Moore, Pancrease MT, Panokase, Ilozyme, Pancrease MT 20, Ultrase, Ultrase MT 12, Pancron D/R, Ultrase MT 18, Arco-Lase, Lipram, Pancrecarb MS-8, Pancrecarb MS-4, Lipram-UL 18, Lipram-CR20, Lipram-UL 12, Lipram-UL 20, Viokase 16, Pancreatil-UL 12, Pangestyme CN 10, Pangestyme CN 20, Pangestyme MT 16, Pangestyme UL 18, Pangestyme EC, Kutrase, Ku-Zyme, Lipram-CR, Plaretase, Viokase 8, Lipram-CR5, Lapase, Dygase, Pancrecarb MS-16, Pangestyme UL 20, Panocaps, Panocaps MT 16, Lipram-CR10, Palcaps 10, Lipram-PN10, Lipram-PN16, Lipram-PN20, Panokase 16

Pancrelipase Levels and Effects while Breastfeeding

Summary of Use during Lactation

Pancrelipase has been used in mothers of breastfed infants with apparent allergy to proteins in breastmilk derived from the maternal diet. This technique seems to have improved symptoms of egg allergy and cow’s milk allergy, such as blood in the stool and colic.[1-3] Pancreatic enzymes are not appreciably absorbed from the mother’s gastrointestinal tract, so should not reach the infant. Expert opinion considers use of pancrelipase to be acceptable during breastfeeding.[4,5]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Des Roches A, Abbott M, Begin P, et al. Oral pancreatic enzyme supplements can reduce excretion of ovalbumin in breast milk. J Investig Allergol Clin Immunol. 2014;24:62–3. [PubMed: 24765885]
2.
Repucci A. Resolution of stool blood in breast-fed infants with maternal ingestion of pancreatic enzymes. J Pediatr Gastroenterol Nutr. 1999;29:500. Abstract.
3.
Schach B, Haight M. Colic and food allergy in the breastfed infant: Is it possible for an exclusively breastfed infant to suffer from food allergy? J Hum Lact. 2002;18:50–2. [PubMed: 11845737]
4.
Middleton PG, Gade EJ, Aguilera C, et al. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020;55:1901208. [PubMed: 31699837]
5.
ABM Clinical Protocol #24. Allergic proctocolitis in the exclusively breastfed infant. Breastfeed Med. 2011;6:435–40. [PubMed: 22050274]

Substance Identification

Substance Name

Pancrelipase

CAS Registry Number

53608-75-6

Drug Class

Breast Feeding

Lactation

Gastrointestinal Agents

Enzymes

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

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