Vericiguat Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 30, 2024.

Applies to vericiguat: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Use an effective form of birth control to keep from getting pregnant while you are using this medicine and for at least 1 month after your last dose. Tell your doctor right away if you think you have become pregnant.

Do not use this medicine together with another soluble guanylate cyclase (sGC) stimulator. Do not use this medicine together with medicine to treat erectile dysfunction (eg, sildenafil). Using these medicines together may cause hypotension (low blood pressure).

Serious side effects of vericiguat

Along with its needed effects, vericiguat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vericiguat:

For healthcare professionals

Applies to vericiguat: oral tablet.

Cardiovascular adverse events

• Very common (10% or more): Hypotension (included blood pressure decreased, diastolic blood pressure decreased, systolic blood pressure decreased, hypotension, orthostatic hypotension; up to 16.4%)
• Common (1% to 10%): Symptomatic hypotension, orthostatic hypotension
• Frequency not reported: Systolic blood pressure reduced^[Ref]

During the study, the mean reduction in systolic blood pressure was about 1 to 2 mmHg greater in patients who received this drug compared with placebo. In the study, hypotension was reported in 16.4% of patients using this drug; this also included orthostatic hypotension, which was reported in 1.3% of patients. Symptomatic hypotension was reported in 9.1% of patients using this drug and was considered a serious adverse event in 1.2% of patients.^[Ref]

Hematologic

• Common (1% to 10%): Anemia (included anemia, macrocytic anemia, anemia of chronic disease, autoimmune hemolytic anemia, blood loss anemia, hemolytic anemia, hypochromic anemia, iron deficiency anemia, microcytic anemia, nephrogenic anemia, normochromic anemia, normochromic normocytic anemia, normocytic anemia, pancytopenia, pernicious anemia, hematocrit decreased, hemoglobin decreased, RBC count decreased)^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, dyspepsia, vomiting, gastroesophageal reflux disease^[Ref]

See also:

Further information

Vericiguat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer