Medically reviewed by Drugs.com. Last updated on Feb 4, 2021.
Applies to the following strengths: 2.5 mg; 5 mg; 10 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Heart Failure
Initial dose: 2.5 mg orally once daily with food
Maintenance dose: Double the dose every 2 weeks to reach the maintenance target dose of 10 mg daily as tolerated.
-Tablets may be crushed and mixed with water if the patient has difficulty swallowing.
Use: To reduce the risk of cardiovascular death and heart failure (HF) hospitalization following a hospitalization for HF or need for outpatient IV diuretics, in adults with symptomatic chronic HF and ejection fraction less than 45%.
Renal Dose Adjustments
-Mild, moderate and severe: No adjustment recommended
-This drug has not been studied in patients with end stage renal disease (CrCl less than 15 mL/min) or on dialysis.
Liver Dose Adjustments
-Mild and moderate liver dysfunction: No dose adjustment recommended
-This drug has not been studied in patients with severe liver dysfunction (Child-Pugh C).
US BOXED WARNINGS:
-This drug may cause fetal harm and should not be administered to a pregnant woman. Females of reproductive potential must exclude pregnancy before treatment initiation. Effective contraception is required during treatment and for one month after the last dose.
-In concomitant use with other soluble guanylate cyclase stimulators (sGC)
Safety and efficacy have not been established in patients younger than 18 years. This drug is not recommended for use in children.
Consult WARNINGS section for additional precautions.
Data not available
-This drug should be taken with food.
-Tablets may be crushed and mixed with water for patients who have difficulty swallowing.
-Store at 20C to 25C (68F to 77F)
-Read the US FDA-approved patient labeling (Patient Information and Instructions for Use).
-If you miss a dose, take it as soon as you remember on the same day of the missed dose.
-Do not take two doses on the same day.
-Females of reproductive potential: Inform your health care provider of known or suspected pregnancy. Use effective contraception during treatment and for one month after the final dose.
-Do not breastfeed during treatment.
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