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VariZIG Side Effects

Generic name: varicella zoster immune globulin

Medically reviewed by Last updated on Jan 31, 2022.

Note: This document contains side effect information about varicella zoster immune globulin. Some of the dosage forms listed on this page may not apply to the brand name VariZIG.

For the Consumer

Applies to varicella zoster immune globulin: intramuscular solution

Side effects requiring immediate medical attention

Along with its needed effects, varicella zoster immune globulin (the active ingredient contained in VariZIG) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking varicella zoster immune globulin:

Less common

  • Chills
  • nausea
  • rash
  • unusual tiredness or weakness

Incidence not known

  • Hives
  • itching
  • redness of the skin
  • shortness of breath
  • swelling of the eyelids, face, lips, hands, or feet

Side effects not requiring immediate medical attention

Some side effects of varicella zoster immune globulin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to varicella zoster immune globulin: intramuscular powder for injection, intramuscular solution


Common (1% to 10%): Injection site pain[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Frequency not reported: Thrombosis[Ref]


Frequency not reported: Nausea[Ref]


Frequency not reported: Rash[Ref]


Frequency not reported: Chills, fatigue[Ref]


1. "Product Information. Varicella Zoster Immune Globulin (varicella zoster immune globulin)." American Red Cross Blood Services, Dedham, MA.

2. "Product Information. Varizig (varicella zoster immune globulin)." Cangene Corporation, Winnipeg, MB.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.