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VariZIG Side Effects

Generic Name: varicella zoster immune globulin

Note: This document contains side effect information about varicella zoster immune globulin. Some of the dosage forms listed on this page may not apply to the brand name VariZIG.

For the Consumer

Applies to varicella zoster immune globulin: intramuscular powder for solution, intramuscular solution

Along with its needed effects, varicella zoster immune globulin (the active ingredient contained in VariZIG) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking varicella zoster immune globulin:

Less common
  • Chills
  • nausea
  • rash
  • unusual tiredness or weakness
Incidence not known
  • Hives
  • itching
  • redness of the skin
  • shortness of breath
  • swelling of the eyelids, face, lips, hands, or feet

Some side effects of varicella zoster immune globulin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Headache
  • pain at the injection site

For Healthcare Professionals

Applies to varicella zoster immune globulin: intramuscular powder for injection, intramuscular solution


Local side effects have included pain, redness and swelling at the injection site.[Ref]


Hypersensitivity side effects have included angioneurotic edema and anaphylactic shock in less than 1 in 1,000 patients.[Ref]


General side effects have included headache, chills, back pain and syncope.[Ref]


Gastrointestinal side effects have included nausea.[Ref]


Dermatologic side effects have included rash.[Ref]


1. "Product Information. Varicella Zoster Immune Globulin (varicella zoster immune globulin)." American Red Cross Blood Services, Dedham, MA.

Some side effects of VariZIG may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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