VariZIG Side Effects

Generic name: varicella zoster immune globulin

Medically reviewed by Drugs.com. Last updated on Nov 16, 2024.

Note: This document provides detailed information about VariZIG Side Effects associated with varicella zoster immune globulin. Some dosage forms listed on this page may not apply specifically to the brand name VariZIG.

Applies to varicella zoster immune globulin: intramuscular solution.

Serious side effects of VariZIG

Along with its needed effects, varicella zoster immune globulin (the active ingredient contained in VariZIG) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking varicella zoster immune globulin:

Less common side effects

• chills
• nausea
• rash
• unusual tiredness or weakness

Incidence not known

• hives
• itching
• redness of the skin
• shortness of breath
• swelling of the eyelids, face, lips, hands, or feet

Other side effects of VariZIG

Some side effects of varicella zoster immune globulin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• headache
• pain at the injection site

For healthcare professionals

Applies to varicella zoster immune globulin: intramuscular powder for injection, intramuscular solution.

General adverse events

The most serious adverse reactions observed in clinical trials included pyrexia, nausea, and vomiting. The most common adverse reactions were injection site pain, headache, rash, fatigue, chills, and nausea.^[Ref]

Cardiovascular

• Frequency not reported: Deep vein thrombosis
• Postmarketing reports: Tachycardia, hypotension

Immune globulins (immunoglobulins):

• Frequency not reported: Arterial/venous thromboembolic events

Arterial and venous thromboembolic events (including myocardial infarction, stroke, deep venous thrombosis, and pulmonary embolism) have been associated with the use of immune globulins.

Dermatologic

• Common (1% to 10%): Rash
• Postmarketing reports: Skin reaction, erythema, itching, pruritus

Immune globulins:

• Frequency not reported: Angioedema, urticaria, skin lesions

Rash included pruritus, rash, erythematous rash, vesicular rash, and urticaria.

Gastrointestinal

• Common (1% to 10%): Nausea
• Frequency not reported: Vomiting
• Postmarketing reports: Nausea, vomiting

Immune globulins:

• Frequency not reported: Nausea

Hematologic

• Frequency not reported: Disseminated intravascular coagulation, coagulopathy

Hypersensitivity

• Frequency not reported: Serum sickness
• Postmarketing reports: Anaphylactic shock, hypersensitivity

Immune globulins:

• Frequency not reported: Generalized hypersensitivity reactions

Local

• Common (1% to 10%): Injection site pain
• Frequency not reported: Local reactions at injection sites
• Postmarketing reports: Injection site swelling, injection site pain, injection site erythema, injection site induration, injection site warmth, injection site pruritus, injection site rash, injection site itching

Local reactions at injection sites included swelling, soreness, redness, induration, local heat, itching, bruising, and rash.

Musculoskeletal

• Postmarketing reports: Arthralgia

Nervous system

• Common (1% to 10%): Headache
• Frequency not reported: Intracranial hemorrhage, intraventricular hemorrhage
• Postmarketing reports: Headache

Immune globulins:

• Frequency not reported: Drowsiness, headache, dizziness, convulsions

Other

• Common (1% to 10%): Fatigue, chills
• Postmarketing reports: Fever, malaise, chills

Immune globulins:

• Frequency not reported: Mild pyrexia, malaise

Respiratory

• Frequency not reported: Pulmonary hemorrhage

Further information

VariZIG side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer