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ProQuad

Generic Name: measles, mumps, rubella and varicella (MMRV) vaccine (MEE zels, MUMPS, roo BEL a, var i SEL a)
Brand Names: ProQuad

Medically reviewed by Philip Thornton, DipPharm. Last updated on Nov 29, 2019.

What is ProQuad vaccine?

ProQuad is a measles, mumps, rubella and varicella virus vaccine. Measles, mumps, rubella, and varicella are serious diseases caused by viruses spread from person to person through the air or by skin to skin contact.

Measles virus can cause minor symptoms such as skin rash, cough, runny nose, eye irritation, or mild fever. It can also cause more serious symptoms such as ear infection, pneumonia, seizures, permanent brain damage, or death.

Mumps virus causes fever, headache, muscle aches, and swollen glands. More more serious symptoms include hearing loss, painful swelling of the testicles or ovaries, swelling around the brain or spinal cord, or (rarely) death.

Rubella virus (also called German Measles) causes skin rash, fever, sore throat, headache, eye irritation, and joint pain. Becoming infected with rubella during pregnancy can result in a miscarriage or serious birth defects.

Varicella (chickenpox) can cause fever, tiredness, headache, loss of appetite, and a breakout of fluid-filled blisters on the skin. Chickenpox is usually mild, but it can lead to severe skin infection, breathing problems, brain damage, or death. A person who has had chickenpox can develop herpes zoster (also called shingles) later in life, which causes severe nerve pain, and hearing or vision problems, which may last for months or years.

The ProQuad vaccine is used to help prevent these diseases in children. This vaccine works by exposing your child to a small dose of the virus or a protein from the virus, which causes the body to develop immunity to the disease. ProQuad will not treat an active infection that has already developed in the body.

ProQuad vaccine is for use in children between the ages of 12 months and 12 years old.

Like any vaccine, ProQuad vaccine may not provide protection from disease in every person.

Important Information

ProQuad vaccine is usually given only once when the child is between 12 months and 12 years old. If a booster dose is needed, At least 3 months should pass between the first and second doses of ProQuad.

Your child should not receive a booster vaccine if he or she had a life threatening allergic reaction after the first shot. Your child can still receive ProQuad if he or she has a minor cold. In the case of a more severe illness with a fever or any type of infection, wait until the child gets better before receiving ProQuad vaccine. Keep track of any and all side effects your child has after receiving ProQuad. If the child ever needs to receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, rubella, or varicella is much more dangerous to your child's health than receiving ProQuad. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Do not give your child salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others for at least 6 weeks after receiving ProQuad. A serious condition called Reye's Syndrome has been reported in patients with chickenpox who take aspirin or salicylates.

Before taking this medicine

Your child should not receive ProQuad if he or she:

  • is allergic to gelatin; or

  • has had a severe allergic reaction to neomycin.

Your child should also not receive ProQuad if he or she has:

  • a cancer such as leukemia or lymphoma;

  • a bone marrow or blood cell disorder;

  • untreated tuberculosis;

  • a history of severe allergic reaction to eggs; or

  • severe immune suppression caused by disease (such as cancer, HIV, or AIDS), or by receiving medicines such as certain steroids, chemotherapy or radiation.

Your child can still receive a vaccine if he or she has a minor cold. In the case of a more severe illness with a fever or any type of infection, wait until the child gets better before receiving this vaccine.

If your child has any of these other conditions, ProQuad may need to be postponed or not given at all:

  • active tuberculosis infection;

  • a history of brain injury or seizures;

  • thrombocytopenia purpura (easy bruising or bleeding); or

  • if you have received an immune globulin or a blood or plasma transfusion within the past 3 months.

Although MMRV vaccine is normally given only to children, a pregnant women should not receive ProQuad. Chickenpox can cause birth defects, low birth weight, or a serious infection in the newborn, and ProQuad exposes you to a small amount of this virus. Any female receiving MMRV vaccine should not get pregnant for 3 months after getting the vaccine.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How is ProQuad given?

ProQuad is given as an injection under the skin. You will receive this injection in a doctor's office or clinic setting.

ProQuad vaccine is usually given only once when the child is 12 to 15 month old. A booster dose may be given between 4 and 6 years of age.

If your child has received any other measles vaccine, at least 1 month should pass between that vaccine and the ProQuad vaccine.

If your child has received any other varicella vaccine, at least 3 months should pass between that vaccine and the ProQuad vaccine.

Your child's booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by your local health department.

ProQuad can cause false results on a skin test for tuberculosis for up to 6 weeks. Tell any doctor who treats you if you have received an MMRV vaccine within the past 4 to 6 weeks.

ProQuad dosing information

Usual Pediatric Dose for Varicella-Zoster - Prophylaxis:

1 dose (0.5 mL) subcutaneously in the outer deltoid or higher anterolateral thigh.

Usual Pediatric Dose for Mumps - Prophylaxis:

1 dose (0.5 mL) subcutaneously in the outer deltoid or higher anterolateral thigh.

Usual Pediatric Dose for Rubella - Prophylaxis:

1 dose (0.5 mL) subcutaneously in the outer deltoid or higher anterolateral thigh.

Usual Pediatric Dose for Measles - Prophylaxis:

1 dose (0.5 mL) subcutaneously in the outer deltoid or higher anterolateral thigh.

Comments:
-The first dose is usually administered at 12 to 15 months of age.
-A second dose, if needed, is usually administered at 4 to 6 years of age.

Use: Active immunization for the prevention of measles, mumps, rubella, and varicella in children 12 months through 12 years of age.

What happens if I miss a dose?

Since ProQuad is usually given only once, you are not likely to miss a dose. Contact your doctor if you do not receive all recommended doses.

What happens if I overdose?

An overdose of ProQuad is unlikely to occur.

What should I avoid before or after receiving ProQuad?

For 6 weeks after receiving ProQuad vaccine:

  • Do not give your child salicylates such as aspirin or similar medicines such as Alka-Seltzer, Doan's Pills, Excedrin, Ecotrin, Nuprin, Dolobid, Tricosal, and others. A serious condition called Reye's Syndrome has been reported in patients with chickenpox who take aspirin or salicylates.

  • Your child should avoid coming into contact with anyone who could easily get infected with chickenpox. This may include newborn babies, pregnant women, and anyone with a weak immune system. ProQuad vaccine may not cause your child to have symptoms of chickenpox. However, there is a chance that varicella virus could be passed from a recently vaccinated child to anyone who may be susceptible to chickenpox.

ProQuad side effects

Get emergency medical help if you have signs of an allergic reaction to ProQuad (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Your child should not receive a booster vaccine if he or she had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects your child has after receiving ProQuad. If the child ever needs to receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, rubella, or varicella is much more dangerous to your child's health than receiving this vaccine. However, like any medicine, ProQuad can cause side effects but the risk of serious side effects is extremely low.

Call your doctor at once if your child has any of these serious side effects:

  • a high fever;

  • easy bruising or bleeding;

  • a light-headed feeling, like you might pass out;

  • a seizure; or

  • nervous system problems - numbness, pain, tingling, weakness, burning or prickly feeling, vision or hearing problems, trouble breathing.

Common ProQuad side effects may include:

  • redness, pain, or swelling where the shot was given;

  • fever;

  • rash; or

  • feeling irritable (fussiness in a young child).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

What other drugs will affect ProQuad vaccine?

MMRV vaccine is sometimes given at the same time as other vaccines. Before receiving ProQuad, tell the doctor about all other vaccines your child has recently received.

Also tell the doctor if your child has recently received drugs or treatments that can weaken the immune system, including:

  • an oral, nasal, inhaled, or injectable steroid medicine;

  • chemotherapy or radiation cancer treatments;

  • medications to treat psoriasis, rheumatoid arthritis, or other autoimmune disorders; or

  • medicines to treat or prevent organ transplant rejection.

If your child is receiving any of these medications, he or she may not be able to receive the vaccine, or may need to wait until the other treatments are finished.

Other drugs may affect MMR vaccine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use ProQuad only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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