Varizig Dosage
Generic name: HUMAN VARICELLA-ZOSTER IMMUNE GLOBULIN 125[iU] in 1.2mL
Dosage form: injection, solution
Drug class: Immune globulins
Medically reviewed by Drugs.com. Last updated on Jan 5, 2024.
For intramuscular use only.
Preparation and Handling
Each vial of VARIZIG contains a minimum potency of 125 international units in 1.2 mL.
Bring VARIZIG to room temperature prior to use.
Inspect VARIZIG for particulate matter and discoloration prior to administration. Do not use if the solution is cloudy or contains particulates.
VARIZIG is for single use only. Discard any unused portion.
Dosing of VARIZIG is based on body weight. Administer a single dose of VARIZIG intramuscularly as recommended in Table 1.
The minimum dose is 62.5 international units for small infants under two kilograms body weight; the maximum dose of 625 international units should be administered for all patients greater than 40 kilograms in weight.
*Extractable volumes are confirmed using a 21 gauge needle as per USP General Chapters <1> Injections. |
||||
≤: less than or equal to |
||||
≥: greater than or equal to |
||||
Weight of Patient | VARIZIG Dose | Volume to Administer* (milliliters) | ||
Kilograms | Pounds | international units | Number of Vials | |
≤2.0 | ≤4.4 | 62.5 | 0.5 | 0.6 |
2.1–10.0 | 4.5–22.0 | 125 | 1 | 1.2 |
10.1–20.0 | 22.1–44.0 | 250 | 2 | 2.4 |
20.1–30.0 | 44.1–66.0 | 375 | 3 | 3.6 |
30.1–40.0 | 66.1–88.0 | 500 | 4 | 4.8 |
≥40.1 | ≥88.1 | 625 | 5 | 6.0 |
Consider a second full dose of VARIZIG for high risk patients who have additional exposures to varicella greater than three weeks after initial VARIZIG administration.
Administration
For intramuscular use only.
Divide the intramuscular dose and administer in two or more injection sites, depending on patient size. Do not exceed 3 milliliters per injection site.
Inject into the deltoid muscle or the anterolateral aspects of the upper thigh. Due to the risk of sciatic nerve injury, do not use the gluteal region as a routine injection site. If the gluteal region is used, only use the upper, outer quadrant.
To prevent the transmission of infectious agents from one person to another, use a new disposable sterile syringe and needle for each individual patient.
More about VariZIG (varicella zoster immune globulin)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Side effects
- During pregnancy
- FDA approval history
- Drug class: immune globulins
- En español
Patient resources
Professional resources
Related treatment guides
See also:
Valtrex
Valtrex is an antiviral drug used to treat infections caused by herpes viruses. Learn about side ...
Zovirax
Zovirax treats viral infections caused by genital herpes, cold sores, shingles, and chicken pox ...
Botox
Botox is used cosmetically to reduce facial lines and wrinkles and for medical purposes for ...
Sitavig
Sitavig (acyclovir) is used to treat cold sores. Includes Sitavig side effects, interactions and ...
GamaSTAN S/D
GamaSTAN S/D is used for hepatitis a, measles, rubella, varicella-zoster
Foscavir
Foscavir is used for CMV Gastroenteritis, CMV Retinitis, herpes simplex ...
ProQuad
ProQuad is a measles, mumps, rubella and varicella virus vaccine. Includes age limits, schedule ...
Varicella virus vaccine
Varicella virus vaccine is used for varicella-zoster, prophylaxis
Immune globulin intramuscular
Immune globulin intramuscular is used for hepatitis a, measles, rubella, varicella-zoster
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.