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Varicella zoster immune globulin Side Effects

For the Consumer

Applies to varicella zoster immune globulin: intramuscular powder for solution, intramuscular solution

As well as its needed effects, varicella zoster immune globulin may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking varicella zoster immune globulin, check with your doctor or nurse immediately:

Less common:
  • Chills
  • nausea
  • rash
  • unusual tiredness or weakness
Incidence not known:
  • Hives
  • itching
  • redness of the skin
  • shortness of breath
  • swelling of the eyelids, face, lips, hands, or feet

Minor Side Effects

Some varicella zoster immune globulin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Headache
  • pain at the injection site

For Healthcare Professionals

Applies to varicella zoster immune globulin: intramuscular powder for injection, intramuscular solution


Local side effects have included pain, redness and swelling at the injection site.[Ref]


Hypersensitivity side effects have included angioneurotic edema and anaphylactic shock in less than 1 in 1,000 patients.[Ref]


General side effects have included headache, chills, back pain and syncope.[Ref]


Gastrointestinal side effects have included nausea.[Ref]


Dermatologic side effects have included rash.[Ref]


1. "Product Information. Varicella Zoster Immune Globulin (varicella zoster immune globulin)." American Red Cross Blood Services, Dedham, MA.

It is possible that some side effects of varicella zoster immune globulin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.