Varicella Zoster Immune Globulin Dosage

Medically reviewed by Drugs.com. Last updated on Aug 16, 2023.

Usual Adult Dose for Varicella-Zoster

Dosing is weight based:

2 kg or less: 62.5 international units intramuscularly
2.1 to 10 kg: 125 international units intramuscularly
10.1 to 20 kg: 250 international units intramuscularly
20.1 to 30 kg: 375 international units intramuscularly
30.1 to 40 kg: 500 international units intramuscularly
40.1 kg or more: 625 international units intramuscularly

Minimum dose: 62.5 international units
Maximum dose: 625 international units

• Consider a second full dose for high risk patients with additional varicella exposures greater than 3 weeks after initial dosing.

Usual Pediatric Dose for Varicella-Zoster

Dosing is weight based:

2 kg or less: 62.5 international units intramuscularly
2.1 to 10 kg: 125 international units intramuscularly
10.1 to 20 kg: 250 international units intramuscularly
20.1 to 30 kg: 375 international units intramuscularly
30.1 to 40 kg: 500 international units intramuscularly
40.1 kg or more: 625 international units intramuscularly

Minimum dose: 62.5 international units
Maximum dose: 625 international units

• Consider a second full dose for high risk patients with additional varicella exposures greater than 3 weeks after initial dosing.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

• Anaphylactic or severe systemic hypersensitivity reactions to human immune globulin preparations
• IgA-deficient patients with antibodies against IgA and a history of hypersensitivity may have an anaphylactoid reaction; this product contains less than 40 mcg/mL of IgA.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• For intramuscular administration only.

Storage requirements: Refrigerate; do not freeze

Reconstitution/preparation techniques:

• Reconstitute only with diluent provided.
• Use within 12 hours of reconstitution if stored at 2 to 8C.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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