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Vanoxide-HC Side Effects

Generic name: benzoyl peroxide / hydrocortisone topical

Medically reviewed by Last updated on Dec 25, 2023.

Note: This document contains side effect information about benzoyl peroxide / hydrocortisone topical. Some dosage forms listed on this page may not apply to the brand name Vanoxide-HC.

Applies to benzoyl peroxide/hydrocortisone topical: external lotion.

Serious side effects of Vanoxide-HC

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects of Vanoxide-HC

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to benzoyl peroxide/hydrocortisone topical: topical kit, topical lotion.


Local side effects are the most common with benzoyl peroxide and have included excessive drying and contact dermatitis.

Local adverse effects of hydrocortisone may include burning, itching, or irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, and miliaria especially if applied to denuded skin or with occlusive dressings.[Ref]

Skin on the face, axillae, and groin appear to be most susceptible to the adverse, long-term effects of topical steroids.

Topical corticosteroid use may inhibit local immune response rendering the skin more susceptible to infections. Folliculitis has occasionally been reported.

Perioral dermatitis or rosacea-like dermatitis has occurred in patients treated with potent topical corticosteroids who are of seborrheic skin type. This condition may flare temporarily upon discontinuation of topical steroids, prompting patients to continue their use. If topical corticosteroids are discontinued, this flare and the initial dermatitis generally resolves over a few weeks.[Ref]


Hypersensitivity reactions have included allergic sensitization in 1% to 5% of patients treated with benzoyl peroxide.[Ref]


Endocrine side effects of topical corticosteroids are rare. Glucose intolerance and hyperglycemia may be induced by corticosteroids. These drugs can rarely suppress the hypothalamic-pituitary-adrenal axis. This suppression is more likely when higher potency topical steroids are used over extensive areas and when occlusive dressings are used.[Ref]

More about Vanoxide-HC (benzoyl peroxide / hydrocortisone topical)

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Related treatment guides


1. (2022) "Product Information. Vanoxide-HC (benzoyl peroxide-hydrocortisone topical)." Dermik Laboratories/Aventis

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.