Uni-Cof Side Effects
Generic name: chlorpheniramine / dihydrocodeine / pseudoephedrine
Note: This document contains side effect information about chlorpheniramine / dihydrocodeine / pseudoephedrine. Some dosage forms listed on this page may not apply to the brand name Uni-Cof.
General side effects including light-headedness, dizziness, drowsiness, headache, fatigue, and sedation have been among the most frequently reported with opioid use. Confusion, abdominal pain, lassitude, giddiness, increased irritability or excitement (especially in children) have been reported. Hallucinations, severe narcosis, and vivid dreams have been reported rarely.[Ref]
Gastrointestinal side effects of chlorpheniramine have included dry mouth and constipation in up to one-third of treated patients.
Gastrointestinal side effects including nausea, vomiting, and constipation have been among the most frequently reported with opioid use. Diarrhea, dry mouth, indigestion, anorexia, spasm of biliary tract have been reported.
Gastrointestinal side effects of pseudoephedrine have included anorexia and gastric irritation in approximately 5% of patients. Dry mouth, nose, or throat have occurred in up to 15% of patients.[Ref]
Nearly all patients treated with chlorpheniramine experience drowsiness. This drowsiness may subside in some patients with extended use.
Few cases of dyskinesias and tremors, often of the face, have been reported in patients whose chronic use of chlorpheniramine extended over a period of 3 to 10 years. Some of these cases were only partially relieved by discontinuation of the drug. Haloperidol was successful in relieving symptoms.[Ref]
Nervous system side effects of chlorpheniramine have included drowsiness in 75% or more of treated patients. Dyskinesias have rarely been reported following chronic use of chlorpheniramine.
Other side effects of dihydrocodeine have included psychological dependence, physical dependence, and tolerance have been reported to develop upon repeated administration.[Ref]
Cardiovascular side effects of pseudoephedrine have included tachycardia. Some patients have developed hypertension and/or arrhythmias.[Ref]
Ocular side effects including miosis and blurred vision have been reported.[Ref]
Hypersensitivity side effects including anaphylactoid reactions have been reported rarely.[Ref]
More about Uni-Cof (chlorpheniramine / dihydrocodeine / pseudoephedrine)
Related treatment guides
1. "Product Information. Hydro-Tussin DHC (chlorpheniramine/dihydrocodeine/PSE)." Ethex Corporation (2022):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.