Ukoniq Side Effects

Generic name: umbralisib

Medically reviewed by Drugs.com. Last updated on Apr 1, 2024.

Note: This document provides detailed information about Ukoniq Side Effects associated with umbralisib. Some dosage forms listed on this page may not apply specifically to the brand name Ukoniq.

Applies to umbralisib: oral tablet.

Important warnings This medicine can cause some serious health issues

Umbralisib affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, or other flu-like symptoms

Get emergency medical help if you have signs of a severe skin reaction such as a fever with skin rash, itching, blistering, peeling, or sores on your skin or mouth.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Call your doctor at once if you have:

• a severe skin rash, or sores on your skin or mouth;

• severe or ongoing diarrhea, stools with mucus or blood, or severe stomach pain;

• liver problems--stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

• low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

• low blood cell counts;

• nausea, vomiting, stomach pain, loss of appetite;

• cold symptoms such as stuffy nose, sneezing, sore throat;

• muscle or bone pain;

• feeling tired; or

• abnormal kidney function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to umbralisib: oral tablet.

General adverse events

• Very common (10% or more): Pyrexia (10%)
• Common (1% to 10%): Sepsis^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (27%)^[Ref]

Metabolic

• Very common (10% or more): Decreased appetite (19%), decreased potassium (21%)^[Ref]

Psychiatric

• Very common (10% or more): Insomnia (14%)^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Hepatic

• Very common (10% or more): Increased alanine aminotransferase (33%), increased aspartate aminotransferase (32%)^[Ref]

Respiratory

• Very common (10% or more): Upper respiratory tract infection (21%)
• Common (1% to 10%): Pneumonia, dyspnea
• Rare (less than 0.1%): Pneumonitis^[Ref]

Hematologic

• Very common (10% or more): Decreased neutrophil decreased (33%), decreased hemoglobin (27%), decrease platelets (26%)
• Common (1% to 10%): Transaminase elevation, neutropenia
• Frequency not reported: Anemia, thrombocytopenia^[Ref]

Nervous system

• Very common (10% or more): Fatigue (41%)^[Ref]

Renal

• Very common (10% or more): Increased creatinine (79%)^[Ref]

Cardiovascular

• Very common (10% or more): Edema (14%)^[Ref]

Dermatologic

• Very common (10% or more): Rash (18%)
• Rare (less than 0.1%): Exfoliative dermatitis^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (58%), nausea (38%), vomiting (21%), abdominal pain (19%)
• Common (1% to 10%): diarrhea, colitis^[Ref]

Further information

Ukoniq side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer