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Twyneo Side Effects

Generic name: benzoyl peroxide / tretinoin topical

Medically reviewed by Last updated on Aug 30, 2022.

Note: This document contains side effect information about benzoyl peroxide / tretinoin topical. Some dosage forms listed on this page may not apply to the brand name Twyneo.

Applies to benzoyl peroxide/tretinoin topical: topical application cream.

Serious side effects of Twyneo

Along with its needed effects, benzoyl peroxide/tretinoin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking benzoyl peroxide/tretinoin topical:

More common

  • Pain, burning, changes in color, dryness, itching, peeling, redness, scaling, stinging, or swelling of the skin where the medicine is applied

Incidence not known

  • Chest tightness
  • cough
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • hives, itching, or skin rash
  • increased sensitivity of the skin to sunlight
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • redness or other discoloration of the skin
  • severe sunburn
  • trouble breathing
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to benzoyl peroxide / tretinoin topical: topical cream.


Postmarketing reports: Anaphylaxis, angioedema, and urticaria[Ref]


Very common (10% or more): Application site pain (10.6%)

Common (1% to 10%): Application Site Dryness, application site exfoliation, application site erythema, application site dermatitis, application site pruritus, application site irritation[Ref]

More about Twyneo (benzoyl peroxide / tretinoin topical)

Patient resources

Professional resources

Related treatment guides


1. "Product Information. Twyneo (benzoyl peroxide-tretinoin topical)." Sol-Gel Technologies Inc. (2021):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.