Tukysa Side Effects

Generic name: tucatinib

Medically reviewed by Drugs.com. Last updated on Sep 28, 2023.

Note: This document contains side effect information about tucatinib. Some dosage forms listed on this page may not apply to the brand name Tukysa.

Applies to tucatinib: oral tablet.

Serious side effects of Tukysa

Along with its needed effects, tucatinib (the active ingredient contained in Tukysa) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tucatinib:

More common

Anxiety
bloody nose
blurred vision
burning, numbness, tingling, or painful sensations
clay colored stools
dark urine
decreased or loss of appetite
dizziness
fever
headache
mood or mental changes
nausea and vomiting
nervousness
pale skin
pounding in the ears
severe diarrhea
skin rash, itching
slow or fast heartbeat
swelling of the feet or lower legs
stomach pain or tenderness
trouble breathing
unsteadiness or awkwardness
unusual bleeding or bruising
unusual tiredness or weakness
weakness of the arms, hands, legs, or feet
yellow eyes or skin

Less common

Muscle spasm or jerking of all extremities
loss of bladder control
seizures
sudden loss of consciousness

Other side effects of Tukysa

Some side effects of tucatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain
chest tightness
constipation
difficulty in moving
flushing
loss of weight
muscle pain or stiffness
pain in the joints
redness, swelling, pain of the skin
scaling of the skin on the hands and feet
swelling or inflammation of the mouth
ulceration of the skin

For Healthcare Professionals

Applies to tucatinib: oral tablet.

Dermatologic

Very common (10% or more): Palmar-plantar erythrodysesthesia syndrome (63%), rash (e.g., rash maculopapular, rash, dermatitis acneiform, erythema, rash macular, rash papular, rash pustular, rash pruritic, rash erythematous, skin exfoliation, urticaria, dermatitis allergic, palmar erythema, plantar erythema, skin toxicity, dermatitis) (20%)^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (81%), nausea (58%), vomiting (36%), stomatitis (e.g., stomatitis, oropharyngeal pain, oropharyngeal discomfort, mouth ulceration, oral pain, lip ulceration, glossodynia, tongue blistering, lip blister, oral dysesthesia, tongue ulceration, aphthous ulcer) (32%)^[Ref]

Hematologic

Very common (10% or more): Hemoglobin decreased (59%), decreased phosphate (57%), anemia (e.g., anemia, hemoglobin decreased, normocytic anemia) (21%)^[Ref]

Hepatic

Very common (10% or more): Bilirubin increased (47%), ALT increased (46%), AST increased (43%), hepatotoxicity (e.g., hyperbilirubinemia, blood bilirubin increased, bilirubin conjugated increased, alanine aminotransferase increased, transaminases increased, hepatotoxicity, aspartate aminotransferase increased, liver function test increased, liver injury, hepatocellular injury) (42%)^[Ref]

Metabolic

Very common (10% or more): Anorexia (25%), weight loss (13%), magnesium decreased (40%), potassium decreased (36%), alkaline phosphate increased (26%)^[Ref]