Tucatinib Side Effects
Medically reviewed by Drugs.com. Last updated on May 14, 2021.
For the Consumer
Applies to tucatinib: oral tablet
Side effects requiring immediate medical attention
Along with its needed effects, tucatinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tucatinib:
- Bloody nose
- burning, numbness, tingling, or painful sensations
- clay colored stools
- dark urine
- decreased or loss of appetite
- mood or mental changes
- nausea and vomiting
- pale skin
- severe diarrhea
- skin rash, itching
- swelling of the feet or lower legs
- stomach pain or tenderness
- troubled breathing with exertion
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- weakness of the arms, hands, legs, or feet
- yellow eyes or skin
- Muscle spasm or jerking of all extremities
- loss of bladder control
- sudden loss of consciousness
Side effects not requiring immediate medical attention
Some side effects of tucatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Difficulty in moving
- loss of weight
- muscle pain or stiffness
- pain in the joints
- redness, swelling, pain of the skin
- scaling of the skin on the hands and feet
- swelling or inflammation of the mouth
- ulceration of the skin
For Healthcare Professionals
Applies to tucatinib: oral tablet
Very common (10% or more): Hemoglobin decreased (59%), decreased phosphate (57%), anemia (e.g., anemia, hemoglobin decreased, normocytic anemia) (21%)[Ref]
Very common (10% or more): Arthralgia (15%)[Ref]
Very common (10% or more): Bilirubin increased (47%), ALT increased (46%), AST increased (43%), hepatotoxicity (e.g., hyperbilirubinemia, blood bilirubin increased, bilirubin conjugated increased, alanine aminotransferase increased, transaminases increased, hepatotoxicity, aspartate aminotransferase increased, liver function test increased, liver injury, hepatocellular injury) (42%)[Ref]
Very common (10% or more): Creatinine increased (33%)[Ref]
Very common (10% or more): Palmar-plantar erythrodysesthesia syndrome (63%), rash (e.g., rash maculopapular, rash, dermatitis acneiform, erythema, rash macular, rash papular, rash pustular, rash pruritic, rash erythematous, skin exfoliation, urticaria, dermatitis allergic, palmar erythema, plantar erythema, skin toxicity, dermatitis) (20%)[Ref]
Very common (10% or more): Diarrhea (81%), nausea (58%), vomiting (36%), stomatitis (e.g., stomatitis, oropharyngeal pain, oropharyngeal discomfort, mouth ulceration, oral pain, lip ulceration, glossodynia, tongue blistering, lip blister, oral dysesthesia, tongue ulceration, aphthous ulcer) (32%)[Ref]
Frequently asked questions
- What’s the difference between tucatinib and neratinib?
- What's the mechanism of action for tucatinib?
More about tucatinib
- Other brands
Related treatment guides
1. "Product Information. Tukysa (tucatinib)." Seattle Genetics Inc, Bothell, WA.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.