Trofinetide Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 23, 2024.

Applies to trofinetide: oral solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly.

This medicine may cause severe diarrhea. Check with your doctor right away if you have fever, pain, stomach cramps, tenderness, or watery or bloody diarrhea. Your doctor will give you medicines to help prevent diarrhea during treatment with this medicine. Drink extra fluids to help prevent dehydration.

This medicine may cause weight loss. Talk to your doctor if you notice you are losing weight during treatment with this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of trofinetide

Along with its needed effects, trofinetide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trofinetide:

Other side effects of trofinetide

Some side effects of trofinetide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to trofinetide: oral liquid.

General adverse events

The most common adverse reactions were diarrhea and vomiting.^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (82%), vomiting (29%)^[Ref]

Metabolic

• Common (1% to 10%): Decreased appetite^[Ref]

Nervous system

• Common (1% to 10%): Seizure^[Ref]

Other

• Common (1% to 10%): Fever^[Ref]

Psychiatric

• Common (1% to 10%): Anxiety, fatigue^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis^[Ref]

See also:

Further information

Trofinetide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer