Trofinetide Side Effects
Medically reviewed by Drugs.com. Last updated on Mar 10, 2025.
Applies to trofinetide: oral solution.
Serious side effects of trofinetide
Along with its needed effects, trofinetide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking trofinetide:
More common side effects
- anxiety
- decreased appetite
- diarrhea
- seizures
- weight loss
Other side effects of trofinetide
Some side effects of trofinetide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
For healthcare professionals
Applies to trofinetide: oral liquid.
General adverse events
The most common adverse reactions were diarrhea and vomiting.[Ref]
Gastrointestinal
- Very common (10% or more): Diarrhea (82%), vomiting (29%)[Ref]
Metabolic
- Common (1% to 10%): Decreased appetite[Ref]
Nervous system
- Common (1% to 10%): Seizure[Ref]
Other
- Common (1% to 10%): Fever[Ref]
Psychiatric
Respiratory
- Common (1% to 10%): Nasopharyngitis[Ref]
References
1. (2023) "Product Information. Daybue (trofinetide)." Acadia Pharmaceuticals
More about trofinetide
- Check interactions
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- Dosage information
- During pregnancy
- Drug class: miscellaneous central nervous system agents
- Breastfeeding
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Further information
Trofinetide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.
