Trecator-SC Side Effects

Generic name: ethionamide

Medically reviewed by Drugs.com. Last updated on Apr 29, 2024.

Note: This document provides detailed information about Trecator-SC Side Effects associated with ethionamide. Some dosage forms listed on this page may not apply specifically to the brand name Trecator-SC.

Applies to ethionamide: oral tablet.

Common side effects of Trecator-SC

Some side effects of ethionamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• increased watering of the mouth
• loss of appetite
• metallic taste
• stomach pain
• swelling or inflammation of the mouth
• weight loss

Incidence not known

• blemishes on the skin
• decreased interest in sexual intercourse
• enlargement of the breasts (in males)
• inability to have or keep an erection
• loss in sexual ability, desire, drive, or performance
• pimples

Serious side effects of Trecator-SC

Along with its needed effects, ethionamide (the active ingredient contained in Trecator-SC) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ethionamide:

Less common side effects

• clumsiness or unsteadiness
• confusion
• mental depression
• numbness, tingling, burning, or pain in the hands and feet
• yellow eyes or skin

Rare side effects

• blindness or vision changes
• blue-yellow color blindness
• blurred vision or loss of vision, with or without eye pain
• burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
• changes in menstrual periods
• chest tightness
• coldness
• decreased sexual ability (in males)
• decreased vision
• difficulty in concentrating
• dry, puffy skin
• fast heartbeat
• fever
• hives, itching, or rash
• hoarseness
• increased hunger
• increased sensitivity of the skin to sunlight
• irritation
• joint pain, stiffness, or swelling
• redness or other discoloration of the skin
• severe sunburn
• shakiness
• swelling of the eyelids, face, lips, hands, or feet
• swelling of the front part of the neck
• trouble breathing or swallowing
• weakness in the hands or feet
• weight gain

Incidence not known

• black, tarry stools
• blistering, peeling, or loosening of the skin
• chest pain
• chills
• cold sweats
• coma
• cool, pale skin
• cough
• dark urine
• diarrhea
• dizziness
• general tiredness and weakness
• headache
• joint or muscle pain
• light-colored stools
• nausea and vomiting
• nightmares
• painful or difficult urination
• red irritated eyes
• red skin lesions, often with a purple center
• seizures
• slurred speech
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips
• swollen glands
• unusual bleeding or bruising
• unusual tiredness or weakness
• upper right abdominal or stomach pain
• yellow eyes and skin

For healthcare professionals

Applies to ethionamide: oral tablet.

General adverse events

The most commonly reported side effects included abdominal pain, diarrhea, nausea, and vomiting.^[Ref]

Gastrointestinal

• Very common (10% or more): Adverse gastrointestinal effects (up to 50%)
• Common (1% to 10%): Abdominal pain, diarrhea, excessive salivation, gastrointestinal disturbances, nausea, stomatitis, vomiting^[Ref]

Approximately 50% of patients are unable to tolerate 1 gram (as a single dose).^[Ref]

Metabolic

• Common (1% to 10%): Anorexia, weight loss
• Rare (0.01% to 0.1%): Pellagra-like syndrome
• Frequency not reported: Hypoglycemia^[Ref]

Nervous system

• Common (1% to 10%): Metallic taste
• Rare (0.01% to 0.1%): Neurotoxic effects, peripheral neuritis
• Frequency not reported: Dizziness, drowsiness, headache^[Ref]

Ocular

• Rare (0.01% to 0.1%): Blurred vision, diplopia, optic neuritis^[Ref]

Dermatologic

• Rare (0.01% to 0.1%): Photosensitivity, rash
• Frequency not reported: Acne^[Ref]

Hematologic

• Rare (0.01% to 0.1%): Purpura, thrombocytopenia^[Ref]

Hypersensitivity

• Rare (0.01% to 0.1%): Hypersensitivity reactions^[Ref]

Hepatic

• Frequency not reported: Hepatitis with/without jaundice, transient ALT increases, transient AST increases, transient serum bilirubin increases^[Ref]

Psychiatric

• Frequency not reported: Mental depression, psychotic disturbances, restlessness^[Ref]

Endocrine

• Frequency not reported: Gynecomastia, hypothyroidism^[Ref]

Cardiovascular

• Frequency not reported: Postural hypotension^[Ref]

Genitourinary

• Frequency not reported: Impotence^[Ref]

Further information

Trecator-SC side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer