TNKase Side Effects

Generic name: tenecteplase

Medically reviewed by Drugs.com. Last updated on May 23, 2024.

Note: This document provides detailed information about TNKase.

Applies to tenecteplase: intravenous powder for solution Side Effects associated with tenecteplase. Some dosage forms listed on this page may not apply specifically to the brand name TNKase.

Applies to tenecteplase: intravenous powder for solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may cause bleeding problems (eg, intracranial hemorrhage). Check with your doctor right away if you have confusion, headache, sudden, nausea or vomiting, or weakness.

Check with your doctor right away if you have pain in the chest, groin, or legs, especially the calves, severe headache, slurred speech, sudden, unexplained trouble breathing, sudden loss of coordination, sudden, severe weakness or numbness in the arm or leg, or vision changes. These may be symptoms of blood clotting problems (eg, thromboembolism).

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, fever or chills, trouble breathing or swallowing, a fast or irregular heartbeat, large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, or any swelling of your hands, face, mouth, or throat with this medicine.

Serious side effects of TNKase

Along with its needed effects, tenecteplase (the active ingredient contained in TNKase) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking tenecteplase:

For healthcare professionals

Applies to tenecteplase: intravenous kit, intravenous powder for injection.

Hematologic adverse events

Major hematological side effects including hematoma (1.7%), gastrointestinal bleeding (>1%), urinary tract bleeding (<1%), puncture site bleeding (<1%), retroperitoneal bleeding (<1%), respiratory tract bleeding (<1%), and unspecified bleeding (<1%) have been reported. Intracranial hemorrhage (ICH) has also been reported. In one study, ICH occurred in 1%, 1.9%, and 3.8% of patients treated with 30, 40, and 50 mg of tenecteplase (the active ingredient contained in TNKase) respectively (patients were also receiving heparin).

Minor hematological side effects including hematoma (12.3%), urinary tract bleeding (3.7%), pharyngeal (3.1%), gastrointestinal tract bleeding (1.9%), epistaxis (1.5%), and unspecified bleeding (1.3%) have been reported.^[Ref]

Cardiovascular

Cardiovascular side effects including cardiogenic shock, arrhythmias, atrioventricular block, heart failure, cardiac arrest, recurrent myocardial ischemia, myocardial reinfarction, myocardial rupture, cardiac tamponade, pericarditis, pericardial effusion, mitral regurgitation, thrombosis, electromechanical dissociation, and hypotension have been reported.^[Ref]

Local

Local side effects including bleeding from the puncture side have been reported.^[Ref]

Respiratory

Respiratory side effects including pulmonary edema have been reported.^[Ref]

See also:

Frequently asked questions

• Is Activase the same as tPA?

Further information

TNKase side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer