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TNKase Dosage

Generic name: TENECTEPLASE 52.5mg in 50mg;
Dosage form: injection
Drug class: Thrombolytics

Medically reviewed by Last updated on Jan 10, 2024.

Recommended Dosage

Initiate treatment as soon as possible after the onset of STEMI symptoms.

TNKase is for intravenous (IV) administration only, administered as a single bolus over 5 seconds. Individualize dosage based on the patient's weight (see Table 1).

Table 1 Recommended Dosage
Patient Weight
Volume TNKase* to be administered (mL)
From one vial of TNKase reconstituted with 10 mL Sterile Water for Injection.
< 60 30 6
≥ 60 to < 70 35 7
≥ 70 to < 80 40 8
≥ 80 to < 90 45 9
≥ 90 50 10


Follow the below steps to prepare TNKase for administration:

Using a sterile syringe, aseptically withdraw 10 mL of Sterile Water for Injection, USP, from the supplied diluent vial. Only use the supplied Sterile Water for Injection, USP for reconstitution.

  • Aseptically reconstitute the TKNase vial with 10 mL Sterile Water for Injection, USP by directing the stream into the lyophilized powder to obtain a final concentration of 5 mg/mL. Slight foaming upon reconstitution is not unusual; any large bubbles will dissipate if the product is allowed to stand undisturbed for several minutes.
  • Gently swirl until contents are completely dissolved. DO NOT SHAKE. The reconstituted preparation results in a colorless to pale yellow transparent solution.
  • Determine the appropriate dose of TNKase [see Dosage and Administration (2.1)] and withdraw this volume (in milliliters) from the reconstituted vial with the syringe. Discard any unused solution.


Follow the below steps for administration of TNKase;

  • Once the appropriate dose of TNKase is drawn into the syringe, inspect the product prior to administration for particulate matter and discoloration.
  • Precipitation may occur when TNKase is administered in an intravenous line containing dextrose. Flush dextrose-containing lines with 0.9% sodium chloride, USP, solution prior to and following single bolus administration of TNKase.
  • Using sterile technique, connect the syringe directly to the intravenous port.
  • Administer reconstituted TNKase as a single intravenous bolus over 5 seconds.
  • Because TNKase contains no antibacterial preservatives, reconstitute immediately before use. If the reconstituted TNKase is not used immediately, refrigerate the TNKase vial at 2°C to 8°C (36°F to 46°F) and use within 8 hours.
  • Dispose of the syringe per established procedures.

Chemical Incompatibilities

TNKase is incompatible with dextrose containing solutions. When used together, precipitation may occur. Flush dextrose containing lines with 0.9% sodium chloride, USP, solution before using TNKase.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.