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Tipiracil / trifluridine Side Effects

In Summary

Commonly reported side effects of tipiracil/trifluridine include: infection, anemia, diarrhea, fatigue, fever, nausea, neutropenia, thrombocytopenia, vomiting, weakness, and decreased appetite. Other side effects include: alopecia, and dysgeusia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to tipiracil / trifluridine: oral tablet

As well as its needed effects, tipiracil / trifluridine may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking tipiracil / trifluridine, check with your doctor immediately:

More common:
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sore throat
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common:
  • Bladder pain
  • bloody or cloudy urine
  • frequent urge to urinate
  • headache
  • muscle aches
  • stuffy or runny nose

Minor Side Effects

Some tipiracil / trifluridine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Abdominal or stomach pain
  • change in taste
  • decreased appetite
  • diarrhea
  • hair loss or thinning of the hair
  • lack or loss of strength
  • loss of taste
  • nausea
  • swelling or inflammation of the mouth
  • vomiting

For Healthcare Professionals

Applies to tipiracil / trifluridine: oral tablet

Hematologic

Very common (10% or more): Anemia (77%), neutropenia (67%), thrombocytopenia (42%)
Common (1% to 10%): Febrile neutropenia[Ref]

Other

Very common (10% or more): Asthenia/fatigue (52%), infections (27%), pyrexia (19%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (48%), diarrhea (32%), vomiting (28%), abdominal pain (21%)
Common (1% to 10%): Stomatitis (8%)[Ref]

General

3.6% of patients discontinued treatment for an adverse event; 13.7% required a dose reduction, most commonly for neutropenia, anemia, febrile neutropenia, fatigue, and diarrhea.[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis, pulmonary emboli
Uncommon (0.1% to 1%): Interstitial lung disease[Ref]

Metabolic

Very common (10% or more): Decreased appetite (39%)[Ref]

Cardiovascular

Common (1% to 10%): QTc interval prolongation[Ref]

Nervous system

Common (1% to 10%): Dysgeusia[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infections[Ref]

Dermatologic

Common (1% to 10%): Alopecia[Ref]

References

1. "Product Information. Lonsurf (tipiracil-trifluridine)." Taiho Oncology, Inc., Princeton, NJ.

It is possible that some side effects of tipiracil / trifluridine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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