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Trifluridine and Tipiracil

Generic Name: Trifluridine and Tipiracil (trye FLURE i deen & tye PIR a sil)
Brand Name: Lonsurf

Medically reviewed on Sep 5, 2018

Uses of Trifluridine and Tipiracil:

See also: Xeloda

What do I need to tell my doctor BEFORE I take Trifluridine and Tipiracil?

  • If you have an allergy to trifluridine and tipiracil or any part of trifluridine and tipiracil.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have liver disease or raised liver enzymes.
  • If you are breast-feeding. Do not breast-feed while you take trifluridine and tipiracil and for 1 day after your last dose.

This is not a list of all drugs or health problems that interact with trifluridine and tipiracil.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take trifluridine and tipiracil with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Trifluridine and Tipiracil?

  • Tell all of your health care providers that you take trifluridine and tipiracil. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Very bad and sometimes life-threatening blood and bone marrow problems like anemia, low platelet counts, or low white blood cell counts have happened with trifluridine and tipiracil. Change in dose or even stopping the drug may be needed if any of these side effects happen. Talk with the doctor.
  • You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • You will need to take special care when handling trifluridine and tipiracil. Check with the doctor or pharmacist to see how to handle trifluridine and tipiracil.
  • If you are 65 or older, use trifluridine and tipiracil with care. You could have more side effects.
  • If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for 3 months after care ends. Use birth control that you can trust.
  • If you are a man and your sex partner gets pregnant while you take trifluridine and tipiracil or within 3 months after your last dose, call your doctor right away.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking trifluridine and tipiracil, call your doctor right away.
  • Use birth control that you can trust to prevent pregnancy while taking trifluridine and tipiracil.

How is this medicine (Trifluridine and Tipiracil) best taken?

Use trifluridine and tipiracil as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take trifluridine and tipiracil within 1 hour after meals.
  • Wear gloves to handle trifluridine and tipiracil.
  • Wash your hands after use.
  • This medicine comes in 2 different strengths. The dose you get may be made up of 2 different strengths. Be sure to take trifluridine and tipiracil as you have been told.
  • To gain the most benefit, do not miss doses.
  • Keep taking trifluridine and tipiracil as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Feeling very tired or weak.
  • Very upset stomach or throwing up.
  • Very loose stools (diarrhea).
  • Very bad belly pain.

What are some other side effects of Trifluridine and Tipiracil?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling tired or weak.
  • Upset stomach or throwing up.
  • Not hungry.
  • Loose stools (diarrhea).
  • Belly pain.
  • Mouth irritation or mouth sores.
  • Change in taste.
  • Hair loss.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Trifluridine and Tipiracil?

  • Store in the original container at room temperature.
  • If stored outside of the original container, throw away any part not used after 30 days.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about trifluridine and tipiracil, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.