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Tinidazole Side Effects

Medically reviewed by Last updated on Jul 27, 2023.

Applies to tinidazole: oral tablet.


Oral route (Tablet)

Carcinogenicity has been seen in mice and rats treated chronically with metronidazole, another nitroimidazole agent. Although such data have not been reported for tinidazole, the two drugs are structurally related and have similar biologic effects. Limit use of tinidazole to approved indication only. Avoid chronic use.

Serious side effects of Tinidazole

Along with its needed effects, tinidazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tinidazole:


Incidence not known

Other side effects of Tinidazole

Some side effects of tinidazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


Incidence not known

For Healthcare Professionals

Applies to tinidazole: compounding powder, oral tablet.


Reported side effects were typically mild, infrequent, and self-limiting. Gastrointestinal side effects were reported most often.[Ref]


Common (1% to 10%): Nausea, dyspepsia/cramps/epigastric discomfort, vomiting, constipation, diarrhea, abdominal pain, flatulence

Rare (0.01% to 0.1%): Furry tongue

Frequency not reported: Tongue discoloration, stomatitis, dryness of mouth, salivation, oral candidiasis, glossitis[Ref]

Nervous system

Common (1% to 10%): Metallic/bitter taste, headache, dizziness, vertigo

Rare (0.01% to 0.1%): Coma

Frequency not reported: Convulsions, peripheral neuropathy, ataxia, giddiness, drowsiness, burning sensation, paresthesia, hypoesthesia/numbness, sensory disturbances, dysgeusia, taste change[Ref]


Common (1% to 10%): Weakness/fatigue/malaise

Frequency not reported: Flushing, fever/pyrexia, thirst, Candida overgrowth, fatigue, malaise[Ref]


Common (1% to 10%): Allergic dermatitis, pruritus

Frequency not reported: Urticaria, rash, sweating, angioedema, fixed drug eruption[Ref]

In a study involving 450 patients with fixed drug eruptions, 8 patients were found to have this oral drug as the probable causative agent. The fixed drug eruptions varied as to duration, shape and size, symptoms, number of lesions, and body site(s) affected. The study did not break these factors down for each individual causative agent.[Ref]


Common (1% to 10%): Anorexia, decreased appetite


Common (1% to 10%): Urinary tract infection, dysuria/painful urination, urine abnormality, pelvic pain, vulvovaginal discomfort, vaginal odor, menorrhagia

Frequency not reported: Darkened urine/chromaturia, increased vaginal discharge, female genital pruritus, Candida vaginitis[Ref]


Common (1% to 10%): Upper respiratory tract infection

Rare (0.01% to 0.1%): Bronchospasm, dyspnea, pharyngitis[Ref]


Rare (0.01% to 0.1%): Confusion, depression

Frequency not reported: Insomnia[Ref]


Rare (0.01% to 0.1%): Reversible thrombocytopenia

Frequency not reported: Neutropenia, leukopenia, increased eosinophil count, decreased hemoglobin[Ref]


Severe acute hypersensitivity reactions have been reported during initial or subsequent exposure to this drug.[Ref]

Frequency not reported: Drug hypersensitivity

Postmarketing reports: Severe acute hypersensitivity reactions, hypersensitivity reactions (included urticaria, pruritus, rash, flushing, sweating, dryness of mouth, fever, burning sensation, thirst, salivation, angioedema, Stevens-Johnson syndrome, erythema multiforme)[Ref]


Frequency not reported: Hepatic abnormalities (included raised transaminase level), increased AST, increased blood bilirubin[Ref]


Frequency not reported: Increased blood urea[Ref]


Frequency not reported: Palpitations[Ref]


Frequency not reported: Arthralgias, myalgias, arthritis[Ref]


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. Tindamax (tinidazole). Presutti Laboratories Inc. 2004.

4. Mahboob A, Haroon TS. Drugs causing fixed eruptions: a study of 450 cases. Int J Dermatol. 1998;37:833-8.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.