Tinidazole Dosage

Usual Adult Dose for Trichomoniasis

2 g orally once

Comments:
-Appropriate diagnostic procedures should be used to identify organism.
-The patient's sexual partner(s) should be treated with the same dose at the same time to prevent reinfection.
-Current guidelines should be consulted for additional information.

Use: For the treatment of trichomoniasis due to Trichomonas vaginalis

Usual Adult Dose for Giardiasis

2 g orally once

Use: For the treatment of giardiasis due to Giardia lamblia

Usual Adult Dose for Amebiasis

2 g orally once a day

Duration of Therapy:
-Intestinal: 3 days
-Amebic liver abscess: 3 to 5 days

Comments:
-This drug is not indicated to treat asymptomatic cyst passage.

Use: For the treatment of intestinal amebiasis and amebic liver abscess due to Entamoeba histolytica

Some Experts Recommend: 2 g orally once a day

Duration of Therapy:
-Mild to moderate intestinal disease: 3 days
-Severe intestinal and extraintestinal disease: 5 days

Comments:
-Treatment with a luminal amebicide should follow this 3- or 5-day therapy.
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Bacterial Vaginosis

2 g orally once a day for 2 days OR 1 g orally once a day for 5 days

Comments:
-Formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, or anaerobic vaginosis
-Should rule out other pathogens commonly associated with vulvovaginitis (e.g., T vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, Candida albicans, Herpes simplex virus)
-Use of this drug in pregnant women has not been studied.

Use: For the treatment of bacterial vaginosis in nonpregnant women

Usual Adult Dose for STD Prophylaxis

US CDC Recommendations: 2 g orally in a single dose

Comments:
-Recommended as part of a regimen for prophylaxis after sexual assault
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Giardiasis

3 years or older: 50 mg/kg orally once
Maximum dose: 2 g/dose

Use: For the treatment of giardiasis due to G lamblia

Usual Pediatric Dose for Amebiasis

3 years or older: 50 mg/kg orally once a day
Maximum dose: 2 g/day

Duration of Therapy:
-Intestinal: 3 days
-Amebic liver abscess: 3 to 5 days

Comments:
-This drug is not indicated to treat asymptomatic cyst passage.
-Limited pediatric data on use beyond 3 days; small number of children treated for 5 days had no additional reported side effects. Close monitoring is recommended when duration of therapy exceeds 3 days.

Use: For the treatment of intestinal amebiasis and amebic liver abscess due to E histolytica

Some Experts Recommend:
3 years or older: 50 mg/kg orally once a day
Maximum dose: 2 g/day

Duration of Therapy:
-Mild to moderate intestinal disease: 3 days
-Severe intestinal and extraintestinal disease: 5 days

Comments:
-Treatment with a luminal amebicide should follow this 3- or 5-day therapy.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Trichomoniasis

Some Experts Recommend: 50 mg/kg orally once
Maximum dose: 2 g/dose

Comments:
-Recommended for trichomoniasis due to T vaginalis
-The patient's sexual partner(s) should be treated with the same dose at the same time.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for STD Prophylaxis

American Academy of Pediatrics Recommendations: 2 g orally in a single dose

Comments:
-Recommended as part of a regimen for postpubertal adolescents as prophylaxis after sexual assault; recommended for trichomoniasis and bacterial vaginosis
-Current guidelines should be consulted for additional information.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Caution recommended.

Precautions

US BOXED WARNING:
-POTENTIAL RISK FOR CARCINOGENICITY: Carcinogenicity observed in mice and rats treated with chronic metronidazole (another nitroimidazole agent); although such data have not been reported for this drug, the 2 drugs are structurally related and have similar biologic effects. Use of this drug should be reserved for approved indications.

Safety and efficacy have not been established in patients younger than 3 years.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis: If this drug is administered the same day as and prior to hemodialysis session, an additional dose equal to 1/2 the recommended dose should be administered after the end of the session.
Peritoneal dialysis: Data not available

Other Comments

Administration advice:
-Administer with food (to minimize epigastric distress and other gastrointestinal side effects); bioavailability not affected by food.
-For patients unable to swallow tablets, may crush the tablets in artificial cherry syrup and administer with food; shake the oral suspension well before each administration.

Storage requirements:
-Store tablets at controlled room temperature 20C to 25C (68F to 77F), excursions permitted to 15C to 30C (59F to 86F); protect from light.
-The oral suspension of crushed tablets in artificial cherry syrup is stable for 7 days at room temperature.

Reconstitution/preparation techniques:
-For extemporaneous pharmacy compounding of the oral suspension:
(a) Crush four 500 mg oral tablets to a powder with mortar and pestle.
(b) Add about 10 mL cherry syrup to the powder and mix until smooth.
(c) Transfer the suspension to a graduated amber container.
(d) Use several small rinses of cherry syrup to transfer any remaining drug in the mortar to the final suspension for a total volume of 30 mL.

Monitoring:
-Hematologic: Total and differential leukocyte counts (if retreatment is necessary)

Patient advice:
-Avoid alcoholic beverages and ethanol- or propylene glycol-containing preparations during therapy and for 72 hours after the last dose.
-Avoid missing doses and complete the entire course of therapy.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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