Tabrecta Side Effects

Generic name: capmatinib

Medically reviewed by Philip Thornton, DipPharm. Last updated on Dec 15, 2024.

Note: This document provides detailed information about Tabrecta.

Applies to capmatinib: oral tablet Side Effects associated with capmatinib. Some dosage forms listed on this page may not apply specifically to the brand name Tabrecta.

Applies to capmatinib: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Use an effective form of birth control during treatment and for at least 1 week after the last dose. Males with female partners who are able to become pregnant should use an effective form of birth control during treatment and for at least 1 week after the last dose. If you think you have become pregnant, tell your doctor right away.

This medicine may cause swelling of the lungs (pneumonitis) or interstitial lung disease. These are life-threatening conditions and require immediate medical attention. The symptoms may be similar to the symptoms from lung cancer. Check with your doctor right away if you have new or worsening cough, fever, or trouble breathing.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, a loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause pancreas problems. Check with your doctor right away if you have bloating, chills, constipation, darkened urine, fast heartbeat, fever, indigestion, loss of appetite, nausea, pains in the stomach, side, or abdomen, possibly radiating to the back, vomiting, or yellow eyes or skin.

This medicine may make your skin more sensitive to sunlight. Use a sunscreen and protective clothing when you are outdoors. Avoid sunlamps and tanning beds.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Tabrecta

Along with its needed effects, capmatinib (the active ingredient contained in Tabrecta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking capmatinib:

Other side effects of Tabrecta

Some side effects of capmatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to capmatinib: oral tablet.

Hematologic adverse events

• Very common (10% or more): Lymphocytes decreased (44%), hemoglobin decreased (24%), leukocytes decreased (23%)^[Ref]

Musculoskeletal

• Very common (10% or more): Noncardiac chest pain (e.g., chest discomfort, musculoskeletal chest pain, noncardiac chest pain, chest pain) (15%), back pain (14%)^[Ref]

Metabolic

• Very common (10% or more): Albumin decreased (68%), creatinine increased (62%), alanine aminotransferase increased (37%), alkaline phosphatase increased (32%), amylase increased (31%), gamma-glutamyltransferase increased (29%), lipase increased (26%), aspartate aminotransferase increased (25%), sodium decreased (23%), phosphate decreased (23%), glucose decreased (21%), weight loss (10%)^[Ref]

Respiratory

• Very common (10% or more): Dyspnea (24%), cough (16%)
• Common (1% to 10%): ILD/pneumonitis^[Ref]

Other

• Very common (10% or more): Peripheral edema (e.g., peripheral swelling, peripheral edema, fluid overload) (52%), fatigue/asthenia (32%), pyrexia/increased body temperature (14%)^[Ref]

Renal

Very common (10% or more):

• Common (1% to 10%): Acute kidney injury (including renal failure)^[Ref]

Dermatologic

• Common (1% to 10%): Pruritus (allergic and generalized), cellulitis, urticaria^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (44%), vomiting (28%), constipation (18%), diarrhea (18%)
• Common (1% to 10%): Acute pancreatitis^[Ref]

See also:

Frequently asked questions

• How effective is Tabrecta?
• Will Tabrecta cure lung cancer?
• Is Tabrecta a chemotherapy drug?

Further information

Tabrecta side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer