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SSD Side Effects

Generic name: silver sulfadiazine topical

Medically reviewed by Last updated on Apr 25, 2024.

Note: This document contains side effect information about silver sulfadiazine topical. Some dosage forms listed on this page may not apply to the brand name SSD.

Applies to silver sulfadiazine topical: topical cream.

Serious side effects of SSD

Along with its needed effects, silver sulfadiazine topical (the active ingredient contained in SSD) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking silver sulfadiazine topical:

Incidence not known

Other side effects of SSD

Some side effects of silver sulfadiazine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to silver sulfadiazine topical: compounding powder, topical cream.


Absorption varies depending upon the percent of body surface area being treated and extent of tissue damage; it is possible any adverse reaction associated with sulfonamides may occur.[Ref]


Common (1% to 10%): Leukopenia

Frequency not reported: Neutrophil count decreased, white blood cell depression, agranulocytosis, aplastic anemia, thrombocytopenia, hemolytic anemia[Ref]


Common (1% to 10%): Pruritus, application site rash, eczema, contact dermatitis

Rare (less than 0.1%): Argyria

Frequency not reported: Skin necrosis, erythema multiforme, skin discoloration, burning sensation, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis[Ref]


Very rare (less than 0.01%): Renal failure

Frequency not reported: Interstitial nephritis[Ref]


Frequency not reported: Hepatitis, hepatocellular necrosis[Ref]

Nervous system

Frequency not reported: Central nervous system reactions[Ref]


Frequency not reported: Gastrointestinal reactions


1. (2001) "Product Information. Silvadene (silver sulfadiazine topical)." Pfizer U.S. Pharmaceuticals Group

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.