Sotatercept Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 10, 2024.

Applies to sotatercept: parenteral powder for injection.

Side effects include:

Most common adverse effects (≥10%): headache, epistaxis, rash, telangiectasia, diarrhea, dizziness, erythema.

For healthcare professionals

Applies to sotatercept: subcutaneous kit.

General adverse events

The most common adverse reactions occurring in 10% of patients or greater included increased hemoglobin, decreased platelets, headache, epistaxis, rash, telangiectasia, diarrhea, dizziness, and erythema.^[Ref]

Cardiovascular

• Frequency not reported: Increased blood pressure

Dermatologic

• Very common (10% or more): Rash (20.2%), telangiectasia (16.6%), erythema (13.5%)

Gastrointestinal

• Very common (10% or more): Diarrhea (15.3%)

Hematologic

• Very common (10% or more): Increased hemoglobin (53%), decreased platelets (25%)
• Common (1% to 10%): Serious bleeding (e.g., gastrointestinal, intracranial hemorrhage), severe thrombocytopenia (platelet count less than 50,000/mm3)

Immunologic

• Very common (10% or more): Antidrug antibodies (27%)
• Common (1% to 10%): Neutralizing antibodies positive

Nervous system

• Very common (10% or more): Headache (24.5%), dizziness (14.7%)

Respiratory

• Very common (10% or more): Epistaxis (22.1%)

Further information

Sotatercept side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer